Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C13H21NO3.ClH |
| Molecular Weight | 275.772 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COC1=C(OC[C@@H](O)CNC(C)C)C=CC=C1
InChI
InChIKey=JKEZSJIWQWVVQR-MERQFXBCSA-N
InChI=1S/C13H21NO3.ClH/c1-10(2)14-8-11(15)9-17-13-7-5-4-6-12(13)16-3;/h4-7,10-11,14-15H,8-9H2,1-3H3;1H/t11-;/m0./s1
| Molecular Formula | C13H21NO3 |
| Molecular Weight | 239.3107 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Levomoprolol (L-moprolol) is a beta-adrenergic blocker which was introduced as an oral medication for treatment of systemic hypertension. It was found to be effective in 2% eyedrops in reducing the intraocular pressure in glaucoma. Observations on glaucoma patients treated with the eyedrop for 1.5 to 2.5 years was without undesirable side effects. L-moprolol and dipivefrin had an equivalent effect in lowering the intraocular pressure. The association of the two drugs caused a further reduction of intraocular pressure.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antihypertensive activity of (-) moprolol in man: double-blind comparison of enantiomers. | 1980 Jul-Aug |
|
| Tolerability of high doses of (-)-moprolol in healthy volunteers. | 1982 |
|
| The pharmacokinetics of dl- and l-moprolol in the human. | 1982 Feb |
|
| [Effects of acute administration of the levogyral beta-blocker levomoprolol on the exercise test in angina pectoris]. | 1984 Dec |
|
| [The beta-blocker levomoprolol in the treatment of glaucoma]. | 1985 |
|
| [Long-term treatment of wide-angle glaucoma with the beta blocker levomoprolol: therapeutic effectiveness without side effects]. | 1986 |
|
| [The hemodynamic effects on the portal system of levomoprolol and propranolol in rats with an enhanced adrenergic tonus]. | 1989 Aug |
|
| Determination by coupled high-performance liquid chromatography-gas chromatography of the beta-blocker levomoprolol in plasma following ophthalmic administration. | 1989 Jul 7 |
|
| Electrophysiological evaluation of the beta-blocking properties and direct membrane effects of l-moprolol and its enantiomer d-moprolol. | 1989 May-Jun |
|
| Identification and determination of the enantiomers of moprolol and their metabolites in human urine by high-performance liquid chromatography and gas chromatography-mass spectrometry. | 1993 Dec 22 |
|
| The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension. | 1994 Nov |
|
| A new catalyst for the asymmetric Henry reaction: synthesis of β-nitroethanols in high enantiomeric excess. | 2012 Dec 21 |
|
| Chemoenzymatic Route for the Synthesis of (S)-Moprolol, a Potential β-Blocker. | 2016 Apr |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:58:08 GMT 2023
by
admin
on
Sat Dec 16 08:58:08 GMT 2023
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| Record UNII |
Y11ZSQ6XK4
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| Record Status |
Validated (UNII)
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m1207
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12866324
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Y11ZSQ6XK4
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113482-87-4
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RACEMATE -> ENANTIOMER |
