FLAVODILOL MALEATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H23NO4.C4H4O4
Molecular Weight	469.4838
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CCCNCC(O)COC1=CC2=C(C=C1)C(=O)C=C(O2)C3=CC=CC=C3

InChI

InChIKey=AEAIVULHCUHDDP-BTJKTKAUSA-N

InChI=1S/C21H23NO4.C4H4O4/c1-2-10-22-13-16(23)14-25-17-8-9-18-19(24)12-20(26-21(18)11-17)15-6-4-3-5-7-15;5-3(6)1-2-4(7)8/h3-9,11-12,16,22-23H,2,10,13-14H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula	C21H23NO4
Molecular Weight	353.4116
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2475704 | https://www.ncbi.nlm.nih.gov/pubmed/2475706

FLAVODILOL is an antihypertensive agent.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 87 Target ID: CHEMBL2095166 Sources: https://adisinsight.springer.com/drugs/800002394	Antagonist 2778		4.0 nM [Ki]

PubMed

Title	Date	PubMed
Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties.	1989 Jan	2909730
Flavodilol: a new antihypertensive agent.	1989 Jul	2475704
Flavodilol: a new antihypertensive agent that preferentially depletes peripheral biogenic amines.	1989 Jul	2475706
Disposition of flavodilol in laboratory animals.	1989 Jul-Aug	2571483

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:19:26 GMT 2023` Edited by `admin` on `Fri Dec 15 16:19:26 GMT 2023`
Record UNII	Y0DFC0D3Q8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLAVODILOL MALEATE

Official Name

English

(±)-7-(2-HYDROXY-3-(PROPYLAMINO)PROPOXY)FLAVONE MALEATE (1:1) (SALT)

Common Name

English

4H-1-BENZOPYRAN-4-ONE, 7-(2-HYDROXY-3-(PROPYLAMINO)PROPOXY)-2-PHENYL-, (±)-, (Z)-2-BUTENEDIOATE (1:1) (SALT)

Common Name

English

PR-877-53OL

Code

English

PR-877-530L

Code

English

FLAVODILOL MALEATE [USAN]

Common Name

English

Code System Code Type Description

FDA UNII

Y0DFC0D3Q8