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Details

Stereochemistry RACEMIC
Molecular Formula C20H35NOS
Molecular Weight 337.563
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULOCTIDIL

SMILES

CCCCCCCCN[C@@H](C)[C@H](O)C1=CC=C(SC(C)C)C=C1

InChI

InChIKey=BFCDFTHTSVTWOG-PXNSSMCTSA-N
InChI=1S/C20H35NOS/c1-5-6-7-8-9-10-15-21-17(4)20(22)18-11-13-19(14-12-18)23-16(2)3/h11-14,16-17,20-22H,5-10,15H2,1-4H3/t17-,20-/m0/s1

HIDE SMILES / InChI
Molecular Formula C20H35NOS
Molecular Weight 337.563
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Suloctidil is considered to be calcium antagonist. In addition to its vascular antispasmodic activity, suloctidil affects blood platelets and enhances brain energy metabolism. Suloctidil was being evaluated in many clinical trials for use in dementia and thrombotic disorders. Suloctidil induces hepatotoxicity.

CNS Activity

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Blocker
537
 0.45 µM [Ki]
Inhibitor
8297
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
Primary
Withdrawn
Unknown

Approved Use

Unknown
Curative
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor.
2004 Feb 15
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
2008 Jan 24
A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.
2013 Feb
Patents

Patents

US4228187
2

Sample Use Guides

In Vivo Use Guide
200 mg t.i.d.
Route of Administration: Oral
In Vitro Use Guide
Suloctidil (10 microM) stimulated the release of prostacyclin (PGI2) from the rabbit aorta, the dog vena cava and the dog portal vein, in vitro.
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:19:40 GMT 2023
Edited
by admin
on Sat Dec 16 17:19:40 GMT 2023
Record UNII
XV1N1XY17K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SULOCTIDIL
INN   MART.   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
Suloctidil [WHO-DD]
Common Name English
DULOCTIL
Brand Name English
OCTAMET
Brand Name English
SULOCTIDIL [MI]
Common Name English
BEMPERIL
Brand Name English
suloctidil [INN]
Common Name English
CP-556S
Code English
IANGENE
Brand Name English
MJF-12637
Code English
SULOCTIDIL [USAN]
Common Name English
SULOCTON
Brand Name English
SULODENE
Brand Name English
BENZENEMETHANOL, 4-((1-METHYLETHYL)THIO)-.ALPHA.-(1-(OCTYLAMINO)ETHYL)-, (R*,S*)-
Systematic Name English
FLUVERSIN
Brand Name English
POLIVASAL
Brand Name English
CEREBRO
Brand Name English
FLUVISCO
Brand Name English
LOCTON
Brand Name English
CIRCLETON
Brand Name English
LOCTIDON
Brand Name English
MJF 12637
Code English
ERYTHRO-P-(ISOPROPYLTHIO)-.ALPHA.-(1-(OCTYLAMINO)ETHYL)BENZYL ALCOHOL
Systematic Name English
EUVASAL
Brand Name English
HEMOANTIN
Brand Name English
SULOCTIDIL [MART.]
Common Name English
DULASI
Brand Name English
SUDIL
Brand Name English
4-((1-METHYLETHYL)THIO)-.ALPHA.-(1-(OCTYLAMINO)ETHYL)BENZENEMETHANOL
Systematic Name English
(±)-SULOCTIDIL
Common Name English
Classification Tree Code System Code
WHO-VATC QC04AX19
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
NCI_THESAURUS C29707
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
WHO-ATC C04AX19
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
Code System Code Type Description
DRUG CENTRAL
2536
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
ChEMBL
CHEMBL588119
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
MESH
D013468
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
PUBCHEM
6604413
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
NCI_THESAURUS
C152466
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
DRUG BANK
DB13340
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
FDA UNII
XV1N1XY17K
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
SMS_ID
100000082955
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
INN
3452
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
MERCK INDEX
m948
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY Merck Index
EVMPD
SUB10752MIG
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
WIKIPEDIA
Suloctidil
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
EPA CompTox
DTXSID4045638
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
CAS
54767-75-8
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
ECHA (EC/EINECS)
259-332-1
Created by admin on Sat Dec 16 17:19:40 GMT 2023 , Edited by admin on Sat Dec 16 17:19:40 GMT 2023
PRIMARY
Related Record Type Details
Structure of SULOCTIDIL HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of SULOCTIDIL
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