Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H19F3N6O |
| Molecular Weight | 404.389 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1COCCN1C2=NC3=C(C=CC=N3)C(NCC4=C(N=CC=C4)C(F)(F)F)=N2
InChI
InChIKey=IZFVCNUAPFSNCO-LBPRGKRZSA-N
InChI=1S/C19H19F3N6O/c1-12-11-29-9-8-28(12)18-26-16-14(5-3-7-24-16)17(27-18)25-10-13-4-2-6-23-15(13)19(20,21)22/h2-7,12H,8-11H2,1H3,(H,24,25,26,27)/t12-/m0/s1
| Molecular Formula | C19H19F3N6O |
| Molecular Weight | 404.389 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 21:25:31 GMT 2025
by
admin
on
Wed Apr 02 21:25:31 GMT 2025
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| Record UNII |
XQ75265YHR
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Systematic Name | English |
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C185291
Created by
admin on Wed Apr 02 21:25:31 GMT 2025 , Edited by admin on Wed Apr 02 21:25:31 GMT 2025
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135240137
Created by
admin on Wed Apr 02 21:25:31 GMT 2025 , Edited by admin on Wed Apr 02 21:25:31 GMT 2025
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XQ75265YHR
Created by
admin on Wed Apr 02 21:25:31 GMT 2025 , Edited by admin on Wed Apr 02 21:25:31 GMT 2025
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2239272-16-1
Created by
admin on Wed Apr 02 21:25:31 GMT 2025 , Edited by admin on Wed Apr 02 21:25:31 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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TARGET ORGANISM->INHIBITOR |
Much quicker kill time than other antibiotics.
EC50
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TARGET ORGANISM->INHIBITOR |
Cell assay. Utilized a mosquito (A. albopictus)-derived cell line (C6/36),stably infected withWolbachia pipientis(wAlbB) with a readout of thepercentage of the cells infected withWolbachi.
EC50
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
WZ1066S is a highly specific anti-Wolbachia candidate. Human trials have demonstrated that depleting>90% of the essential nem-atode endosymbiont bacterium,Wolbachia, using antibiotics, can lead to permanent sterilization of adult female parasites and a safe macrofilaricidal outcome.
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