NITIDINE CHLORIDE

[Cl-].COC1=C(OC)C=C2C(=C1)C=[N+](C)C3=C2C=CC4=C3C=C5OCOC5=C4

InChIKey=QLDAACVSUMUMOR-UHFFFAOYSA-M

InChI=1S/C21H18NO4.ClH/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
DNA topoisomerase II 66 Target ID: CHEMBL2094255 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30132517	Inhibitor 8297
DNA topoisomerase I 59 Target ID: CHEMBL1781 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30132517	Inhibitor 8297
DOPA decarboxylase 15 Target ID: CHEMBL1843 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24794108	Inhibitor 8297	1.34 mM [IC50]

PubMed

Title	Date	PubMed
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.	1991 Jan-Feb	1710653
Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.	1999 Dec	10582872

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:53:52 GMT 2023` Edited by `admin` on `Sat Dec 16 07:53:52 GMT 2023`
Record UNII	XO8WQL69T8
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

NITIDINE CHLORIDE

Common Name

English

NSC-146397

Code

English

1,3)BENZODIOXOLO(5,6-C)PHENANTHRIDINIUM, 2,3-DIMETHOXY-12-METHYL-, CHLORIDE (1:1)

Systematic Name

English

Code System Code Type Description

CAS

13063-04-2