NITIDINE

COC1=CC2=C[N+](C)=C3C4=CC5=C(OCO5)C=C4C=CC3=C2C=C1OC

InChIKey=KKMPSGJPCCJYRV-UHFFFAOYSA-N

InChI=1S/C21H18NO4/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22/h4-10H,11H2,1-3H3/q+1

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
DNA topoisomerase II 66 Target ID: CHEMBL2094255 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30132517	Inhibitor 8504
DNA topoisomerase I 60 Target ID: CHEMBL1781 Sources: https://www.ncbi.nlm.nih.gov/pubmed/30132517	Inhibitor 8504
DOPA decarboxylase 15 Target ID: CHEMBL1843 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24794108	Inhibitor 8504	1.34 mM [IC50]

PubMed

Title	Date	PubMed
Biological activities of nitidine, a potential anti-malarial lead compound.	2012-03-09	22404785
Benzo[c]phenanthridine bases and their antituberculosis activity.	2001-01	11135299
Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.	1999-12	10582872
HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products.	1992-05-29	1376118
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.	1991-01-01	1710653

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:07:50 GMT 2025` Edited by `admin` on `Mon Mar 31 19:07:50 GMT 2025`
Record UNII	933301178Z
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

NITIDINE

Common Name

English

NITIDIN

Preferred Name

English

(1,3)BENZODIOXOLO(5,6-C)PHENANTHRIDINIUM, 2,3-DIMETHOXY-12-METHYL-

Systematic Name

English

NITIDINE CATION

Common Name

English

NITIDINE ION

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID60218846