Telikibart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 21:17:45 GMT 2025` Edited by `admin` on `Wed Apr 02 21:17:45 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	XLJ7694SEX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma1 heavy chain Homo sapiens (1-455) [VH (Homo sapiens IGHV3-23*04 (92.9%) -(IGHD) -IGHJ6*01 (82.4%), CDR-IMGT [8.8.18] (26-33.51-58.97-114)) (1-125) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v39 CH2 F1.3, E1.2, S116 (CH1 R120 (2

Preferred Name

English

Telikibart

Official Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens IL4R (interleukin 4 receptor, IL4RA, IL-4RA, interleukin 13 receptor, CD124)], Homo sapiens monoclonal antibody

Common Name

English

Immunoglobulin G1 [242-phenylalanine,243-glutamic acid,339-serine], anti-(human interleukin 4 receptor subunit ?) (human monoclonal GR1802 ?1-chain), disulfide with human monoclonal GR1802 ?-chain, dimer

Common Name

English

telikibart [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000056816

Created by admin on Wed Apr 02 21:17:45 GMT 2025 , Edited by admin on Wed Apr 02 21:17:45 GMT 2025

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FDA UNII

XLJ7694SEX

Created by admin on Wed Apr 02 21:17:45 GMT 2025 , Edited by admin on Wed Apr 02 21:17:45 GMT 2025

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NCI_THESAURUS

C211820

Created by admin on Wed Apr 02 21:17:45 GMT 2025 , Edited by admin on Wed Apr 02 21:17:45 GMT 2025

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INN

13144

Created by admin on Wed Apr 02 21:17:45 GMT 2025 , Edited by admin on Wed Apr 02 21:17:45 GMT 2025

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CAS

2618667-96-0

Created by admin on Wed Apr 02 21:17:45 GMT 2025 , Edited by admin on Wed Apr 02 21:17:45 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_152	2_208
2_228	4_219
2_269	2_329
1_152	1_208
2_375	2_433
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_228	3_219
1_234	2_234
1_237	2_237
1_269	1_329
1_375	1_433

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_305
N	2_305

Related Record Type Details


					2HR7ATK059

INTERLEUKIN-4 RECEPTOR SUBUNIT ALPHA

TARGET -> INHIBITOR

Comments:

anti-inflammatory

Amount:

Related Record Type Details


					XLJ7694SEX

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_455] [2_455]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL