FASIPLON

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H15N5O2
Molecular Weight	273.2905
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=C(C)N2C=C(N=C2N=C1OC)C3=NOC(C)=N3

InChI

InChIKey=MEBYKPLMXIRYRQ-UHFFFAOYSA-N

InChI=1S/C13H15N5O2/c1-5-9-7(2)18-6-10(11-14-8(3)20-17-11)15-13(18)16-12(9)19-4/h6H,5H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C13H15N5O2
Molecular Weight	273.2905
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1648620 | https://www.ncbi.nlm.nih.gov/pubmed/16272224 | https://www.ncbi.nlm.nih.gov/pubmed/15451405 | https://adisinsight.springer.com/drugs/800003608

Fasiplon (RU 33203), an imidazo[1,2-a]pyrimidine derivative, is agonist of GABA(A) receptors at benzodiazepine binding site. It was in preclinical studies for the treatment of anxiety.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacological properties of GABAA receptors containing gamma1 subunits.	2006-02	16272224
Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.	2004-10-15	15451405
Discriminative stimulus properties of RU 33965, a benzodiazepine receptor weak partial inverse agonist.	1992-10	1359581
2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors.	1991-07	1648620

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:14:14 GMT 2025` Edited by `admin` on `Mon Mar 31 18:14:14 GMT 2025`
Record UNII	XCA050IPGB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FASIPLON

Official Name

English

fasiplon [INN]

Preferred Name

English

6-ETHYL-7-METHOXY-5-METHYL-2-(5-METHYL-1,2,4-OXADIAZOL-3-YL)IMIDAZO(1,2-A)PYRIMIDINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197