FASIPLON

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H15N5O2
Molecular Weight	273.2905
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=C(C)N2C=C(N=C2N=C1OC)C3=NOC(C)=N3

InChI

InChIKey=MEBYKPLMXIRYRQ-UHFFFAOYSA-N

InChI=1S/C13H15N5O2/c1-5-9-7(2)18-6-10(11-14-8(3)20-17-11)15-13(18)16-12(9)19-4/h6H,5H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C13H15N5O2
Molecular Weight	273.2905
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1648620 | https://www.ncbi.nlm.nih.gov/pubmed/16272224 | https://www.ncbi.nlm.nih.gov/pubmed/15451405 | https://adisinsight.springer.com/drugs/800003608

Fasiplon (RU 33203), an imidazo[1,2-a]pyrimidine derivative, is agonist of GABA(A) receptors at benzodiazepine binding site. It was in preclinical studies for the treatment of anxiety.

Originator

Approval Year

PubMed

Title	Date	PubMed
2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors.	1991 Jul	1648620
Discriminative stimulus properties of RU 33965, a benzodiazepine receptor weak partial inverse agonist.	1992 Oct	1359581
Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.	2004 Oct 15	15451405
Pharmacological properties of GABAA receptors containing gamma1 subunits.	2006 Feb	16272224

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:56:57 UTC 2023` Edited by `admin` on `Fri Dec 15 15:56:57 UTC 2023`
Record UNII	XCA050IPGB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FASIPLON

Official Name

English

6-ETHYL-7-METHOXY-5-METHYL-2-(5-METHYL-1,2,4-OXADIAZOL-3-YL)IMIDAZO(1,2-A)PYRIMIDINE

Systematic Name

English

fasiplon [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197