Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H5ClN5O2.Na |
| Molecular Weight | 321.654 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].ClC1=C2OC3=C(C=CC=N3)C(=O)C2=CC(=C1)C4=NN=N[N-]4
InChI
InChIKey=LAEVCGNXDKGJQI-UHFFFAOYSA-N
InChI=1S/C13H5ClN5O2.Na/c14-9-5-6(12-16-18-19-17-12)4-8-10(20)7-2-1-3-15-13(7)21-11(8)9;/h1-5H;/q-1;+1
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C13H6ClN5O2 |
| Molecular Weight | 299.672 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Traxanox is a diuretic agent possessing an uricosuric effect in animals. The diuretic and uricosuric effects of the drug have also been demonstrated in normotensive healthy subjects. The chronic administration of traxanox reduces serum uric acid level as well as blood pressure in patients with mild to moderate hypertension. This reduction in serum uric acid is due in part to a traxanox-induced elevation of urinary uric acid excretion. Traxanox sodium stimulates the phagocytic activity of leukocytes or macrophages and prevents the drug-induced suppression of the phagocytic activity of these cells. Traxanox may be clinically effective in treating patients with nasal allergies. The mode of action of traxanox on inflammatory responses resembles that of D-penicillamine or levamisole, so that it may prove to be clinically effective in treating rheumatoid arthritis. Also, traxanox may be effective for the treatment of allergic bronchial asthma.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of traxanox sodium on blood pressure and serum uric acid in hypertensive patients: a preliminary study. | 1989-04 |
|
| Stimulation of phagocytic activity of leukocytes and macrophages by traxanox sodium in mice and rats. | 1989-02 |
|
| Different inhibitory actions of immunomodulating agents and immunosuppressive agents on bone resorption of mouse calvaria. | 1989 |
|
| [Effects of traxanox sodium on experimental nasal allergy]. | 1988-07 |
|
| Diuretic and uricosuric effects of traxanox sodium in healthy subjects. Single dose study. | 1987-12 |
|
| Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. | 1987-02 |
|
| [Restorative effect of traxanox on the suppression of antibody production in BALB/c mice]. | 1986-01 |
|
| [Effect of traxanox sodium on inflammatory response]. | 1985-11 |
|
| [Effect of traxanox on antibody formation in C57BL/6 mice]. | 1985-02 |
|
| [General pharmacological actions of traxanox sodium. II. Effects on the cardiovascular system]. | 1983-07 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:53:53 GMT 2025
by
admin
on
Mon Mar 31 19:53:53 GMT 2025
|
| Record UNII |
X9PB9F42LL
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
70502-82-8
Created by
admin on Mon Mar 31 19:53:53 GMT 2025 , Edited by admin on Mon Mar 31 19:53:53 GMT 2025
|
PRIMARY | |||
|
330806
Created by
admin on Mon Mar 31 19:53:53 GMT 2025 , Edited by admin on Mon Mar 31 19:53:53 GMT 2025
|
PRIMARY | |||
|
X9PB9F42LL
Created by
admin on Mon Mar 31 19:53:53 GMT 2025 , Edited by admin on Mon Mar 31 19:53:53 GMT 2025
|
PRIMARY | |||
|
13179970
Created by
admin on Mon Mar 31 19:53:53 GMT 2025 , Edited by admin on Mon Mar 31 19:53:53 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |