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Details

Stereochemistry ACHIRAL
Molecular Formula C13H5ClN5O2.Na
Molecular Weight 321.654
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRAXANOX SODIUM

SMILES

[Na+].ClC1=C2OC3=C(C=CC=N3)C(=O)C2=CC(=C1)C4=NN=N[N-]4

InChI

InChIKey=LAEVCGNXDKGJQI-UHFFFAOYSA-N
InChI=1S/C13H5ClN5O2.Na/c14-9-5-6(12-16-18-19-17-12)4-8-10(20)7-2-1-3-15-13(7)21-11(8)9;/h1-5H;/q-1;+1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.98976928
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C13H6ClN5O2
Molecular Weight 299.672
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Traxanox is a diuretic agent possessing an uricosuric effect in animals. The diuretic and uricosuric effects of the drug have also been demonstrated in normotensive healthy subjects. The chronic administration of traxanox reduces serum uric acid level as well as blood pressure in patients with mild to moderate hypertension. This reduction in serum uric acid is due in part to a traxanox-induced elevation of urinary uric acid excretion. Traxanox sodium stimulates the phagocytic activity of leukocytes or macrophages and prevents the drug-induced suppression of the phagocytic activity of these cells. Traxanox may be clinically effective in treating patients with nasal allergies. The mode of action of traxanox on inflammatory responses resembles that of D-penicillamine or levamisole, so that it may prove to be clinically effective in treating rheumatoid arthritis. Also, traxanox may be effective for the treatment of allergic bronchial asthma.

Approval Year

PubMed

PubMed

TitleDatePubMed
Effects of traxanox sodium on blood pressure and serum uric acid in hypertensive patients: a preliminary study.
1989-04
Stimulation of phagocytic activity of leukocytes and macrophages by traxanox sodium in mice and rats.
1989-02
Different inhibitory actions of immunomodulating agents and immunosuppressive agents on bone resorption of mouse calvaria.
1989
[Effects of traxanox sodium on experimental nasal allergy].
1988-07
Diuretic and uricosuric effects of traxanox sodium in healthy subjects. Single dose study.
1987-12
Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol.
1987-02
[Restorative effect of traxanox on the suppression of antibody production in BALB/c mice].
1986-01
[Effect of traxanox sodium on inflammatory response].
1985-11
[Effect of traxanox on antibody formation in C57BL/6 mice].
1985-02
[General pharmacological actions of traxanox sodium. II. Effects on the cardiovascular system].
1983-07
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:53:53 GMT 2025
Edited
by admin
on Mon Mar 31 19:53:53 GMT 2025
Record UNII
X9PB9F42LL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Y-12141
Preferred Name English
TRAXANOX SODIUM
Common Name English
Y12141
Code English
5H-(1)BENZOPYRANO(2,3-B)PYRIDIN-5-ONE, 9-CHLORO-7-(1H-TETRAZOL-5-YL)-, SODIUM SALT
Common Name English
TRAXANOX SODIUM PENTAHYDRATE
Common Name English
SODIUM 9-CHLORO-7-(1H-TETRAZOL-5-YL)-5H-(1)BENZOPYRANO(2,3-B)PYRIDINE-5-OLATE
Systematic Name English
NSC-330806
Code English
TRAXANOX SODIUM PENTAHYDRATE [JAN]
Common Name English
Code System Code Type Description
CAS
70502-82-8
Created by admin on Mon Mar 31 19:53:53 GMT 2025 , Edited by admin on Mon Mar 31 19:53:53 GMT 2025
PRIMARY
NSC
330806
Created by admin on Mon Mar 31 19:53:53 GMT 2025 , Edited by admin on Mon Mar 31 19:53:53 GMT 2025
PRIMARY
FDA UNII
X9PB9F42LL
Created by admin on Mon Mar 31 19:53:53 GMT 2025 , Edited by admin on Mon Mar 31 19:53:53 GMT 2025
PRIMARY
PUBCHEM
13179970
Created by admin on Mon Mar 31 19:53:53 GMT 2025 , Edited by admin on Mon Mar 31 19:53:53 GMT 2025
PRIMARY
Related Record Type Details
ACTIVE MOIETY