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Details

Stereochemistry ACHIRAL
Molecular Formula C13H6ClN5O2
Molecular Weight 299.672
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRAXANOX

SMILES

ClC1=CC(=CC2=C1OC3=NC=CC=C3C2=O)C4=NN=NN4

InChI

InChIKey=MLCGWPUVZKTVLO-UHFFFAOYSA-N
InChI=1S/C13H6ClN5O2/c14-9-5-6(12-16-18-19-17-12)4-8-10(20)7-2-1-3-15-13(7)21-11(8)9/h1-5H,(H,16,17,18,19)

HIDE SMILES / InChI

Molecular Formula C13H6ClN5O2
Molecular Weight 299.672
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Traxanox is a diuretic agent possessing an uricosuric effect in animals. The diuretic and uricosuric effects of the drug have also been demonstrated in normotensive healthy subjects. The chronic administration of traxanox reduces serum uric acid level as well as blood pressure in patients with mild to moderate hypertension. This reduction in serum uric acid is due in part to a traxanox-induced elevation of urinary uric acid excretion. Traxanox sodium stimulates the phagocytic activity of leukocytes or macrophages and prevents the drug-induced suppression of the phagocytic activity of these cells. Traxanox may be clinically effective in treating patients with nasal allergies. The mode of action of traxanox on inflammatory responses resembles that of D-penicillamine or levamisole, so that it may prove to be clinically effective in treating rheumatoid arthritis. Also, traxanox may be effective for the treatment of allergic bronchial asthma.

Approval Year

PubMed

PubMed

TitleDatePubMed
[General pharmacological actions of traxanox sodium. II. Effects on the cardiovascular system].
1983 Jul
[Effects of traxanox sodium on experimental nasal allergy].
1988 Jul
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:49:58 GMT 2023
Edited
by admin
on Fri Dec 15 15:49:58 GMT 2023
Record UNII
HDU53A8A4S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRAXANOX
INN   MI  
INN  
Official Name English
traxanox [INN]
Common Name English
TRAXANOX [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29712
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
Code System Code Type Description
MESH
C020178
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
DRUG CENTRAL
3622
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
INN
4932
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
NCI_THESAURUS
C66616
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
SMS_ID
100000077495
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
PUBCHEM
68784
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
CAS
58712-69-9
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
EPA CompTox
DTXSID50207421
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
EVMPD
SUB11221MIG
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
FDA UNII
HDU53A8A4S
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
ChEMBL
CHEMBL2009696
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY
MERCK INDEX
m11009
Created by admin on Fri Dec 15 15:49:58 GMT 2023 , Edited by admin on Fri Dec 15 15:49:58 GMT 2023
PRIMARY Merck Index
Related Record Type Details
ACTIVE MOIETY