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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H29N3O4
Molecular Weight 495.569
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GW-1929

SMILES

CN(CCOC1=CC=C(C[C@H](NC2=CC=CC=C2C(=O)C3=CC=CC=C3)C(O)=O)C=C1)C4=NC=CC=C4

InChI

InChIKey=QTQMRBZOBKYXCG-MHZLTWQESA-N
InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1

HIDE SMILES / InChI

Molecular Formula C30H29N3O4
Molecular Weight 495.569
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
8.84 null [pKi]
6.15 null [pKi]
PubMed

PubMed

TitleDatePubMed
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.
2002 Jul 15
PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium.
2010 May 1
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.
2010 Sep
Rosiglitazone reverses salbutamol-induced β(2) -adrenoceptor tolerance in airway smooth muscle.
2011 Jan
Bezafibrate restores the inhibition of FSH-induced follicular development and steroidogenesis by tumor necrosis factor-alpha through peroxisome proliferator-activated receptor-gamma pathway in an in vitro mouse preantral follicle culture.
2011 Nov
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:11:52 GMT 2023
Edited
by admin
on Sat Dec 16 08:11:52 GMT 2023
Record UNII
X8S066WKF4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GW-1929
Common Name English
L-TYROSINE, N-(2-BENZOYLPHENYL)-O-(2-(METHYL-2-PYRIDINYLAMINO)ETHYL)-
Systematic Name English
N-(2-BENZOYLPHENYL)-O-(2-(METHYL-2-PYRIDINYLAMINO)ETHYL)-L-TYROSINE
Systematic Name English
Code System Code Type Description
PUBCHEM
6518171
Created by admin on Sat Dec 16 08:11:52 GMT 2023 , Edited by admin on Sat Dec 16 08:11:52 GMT 2023
PRIMARY
CAS
196808-24-9
Created by admin on Sat Dec 16 08:11:52 GMT 2023 , Edited by admin on Sat Dec 16 08:11:52 GMT 2023
PRIMARY
FDA UNII
X8S066WKF4
Created by admin on Sat Dec 16 08:11:52 GMT 2023 , Edited by admin on Sat Dec 16 08:11:52 GMT 2023
PRIMARY
EPA CompTox
DTXSID9043803
Created by admin on Sat Dec 16 08:11:52 GMT 2023 , Edited by admin on Sat Dec 16 08:11:52 GMT 2023
PRIMARY
Related Record Type Details
TRANSPORTER -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY