Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C30H29N3O4 |
Molecular Weight | 495.569 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(CCOC1=CC=C(C[C@H](NC2=CC=CC=C2C(=O)C3=CC=CC=C3)C(O)=O)C=C1)C4=NC=CC=C4
InChI
InChIKey=QTQMRBZOBKYXCG-MHZLTWQESA-N
InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
Molecular Formula | C30H29N3O4 |
Molecular Weight | 495.569 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9836620 |
8.84 null [pKi] | ||
Target ID: CHEMBL3979 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9836620 |
6.15 null [pKi] |
PubMed
Title | Date | PubMed |
---|---|---|
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. | 2002 Jul 15 |
|
PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium. | 2010 May 1 |
|
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. | 2010 Sep |
|
Rosiglitazone reverses salbutamol-induced β(2) -adrenoceptor tolerance in airway smooth muscle. | 2011 Jan |
|
Bezafibrate restores the inhibition of FSH-induced follicular development and steroidogenesis by tumor necrosis factor-alpha through peroxisome proliferator-activated receptor-gamma pathway in an in vitro mouse preantral follicle culture. | 2011 Nov |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:11:52 GMT 2023
by
admin
on
Sat Dec 16 08:11:52 GMT 2023
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Record UNII |
X8S066WKF4
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Record Status |
Validated (UNII)
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Record Version |
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6518171
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196808-24-9
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X8S066WKF4
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DTXSID9043803
Created by
admin on Sat Dec 16 08:11:52 GMT 2023 , Edited by admin on Sat Dec 16 08:11:52 GMT 2023
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TRANSPORTER -> INHIBITOR |
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