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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H29N3O4
Molecular Weight 495.5701
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GW-1929

SMILES

CN(CCOc1ccc(cc1)C[C@@]([H])(C(=O)O)Nc2ccccc2C(=O)c3ccccc3)c4ccccn4

InChI

InChIKey=QTQMRBZOBKYXCG-MHZLTWQESA-N
InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1

HIDE SMILES / InChI

Molecular Formula C30H29N3O4
Molecular Weight 495.5701
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
8.84 null [pKi]
6.15 null [pKi]
PubMed

PubMed

TitleDatePubMed
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
1999 Jul
Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes.
2002 Jan
Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway.
2003 Jul 15
Pituitary resistin gene expression is upregulated in vitro and in vivo by dexamethasone but is unaffected by rosiglitazone.
2005
Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma.
2008 Feb
In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886).
2008 May
Role of G protein-coupled receptor kinase-2 in peroxisome proliferator-activated receptor gamma-mediated modulation of blood pressure and renal vascular reactivity in SHR.
2009
DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer.
2010 Jan 6
PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium.
2010 May 1
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.
2010 Sep
Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.
2011 Aug
Rosiglitazone reverses salbutamol-induced β(2) -adrenoceptor tolerance in airway smooth muscle.
2011 Jan
Bezafibrate restores the inhibition of FSH-induced follicular development and steroidogenesis by tumor necrosis factor-alpha through peroxisome proliferator-activated receptor-gamma pathway in an in vitro mouse preantral follicle culture.
2011 Nov
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:40:39 UTC 2021
Edited
by admin
on Sat Jun 26 04:40:39 UTC 2021
Record UNII
X8S066WKF4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GW-1929
Common Name English
L-TYROSINE, N-(2-BENZOYLPHENYL)-O-(2-(METHYL-2-PYRIDINYLAMINO)ETHYL)-
Systematic Name English
N-(2-BENZOYLPHENYL)-O-(2-(METHYL-2-PYRIDINYLAMINO)ETHYL)-L-TYROSINE
Systematic Name English
Code System Code Type Description
PUBCHEM
6518171
Created by admin on Sat Jun 26 04:40:39 UTC 2021 , Edited by admin on Sat Jun 26 04:40:39 UTC 2021
PRIMARY
CAS
196808-24-9
Created by admin on Sat Jun 26 04:40:39 UTC 2021 , Edited by admin on Sat Jun 26 04:40:39 UTC 2021
PRIMARY
FDA UNII
X8S066WKF4
Created by admin on Sat Jun 26 04:40:39 UTC 2021 , Edited by admin on Sat Jun 26 04:40:39 UTC 2021
PRIMARY
EPA CompTox
196808-24-9
Created by admin on Sat Jun 26 04:40:39 UTC 2021 , Edited by admin on Sat Jun 26 04:40:39 UTC 2021
PRIMARY
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