Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H10N2O8S2 |
Molecular Weight | 422.389 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(=O)(=O)C1=CC=C2N\C(C(=O)C2=C1)=C3\NC4=CC=C(C=C4C3=O)S(O)(=O)=O
InChI
InChIKey=CFZXDJWFRVEWSR-BUHFOSPRSA-N
InChI=1S/C16H10N2O8S2/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14/h1-6,17-18H,(H,21,22,23)(H,24,25,26)/b14-13+
Molecular Formula | C16H10N2O8S2 |
Molecular Weight | 422.389 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Indigotindisulfonic acid (also known as Indigo carmine) is a synthetic dye discovered in 18th century. It is used in many countiries as a food colorant and a pH indicator. In medicine the dye is used to localize ureteral orifices during cystoscopy and ureteral catheterization. In June 2014 the FDA announced the shortage of indigotindisulfonic acid.
CNS Activity
Originator
Approval Year
PubMed
Title | Date | PubMed |
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REFINEMENT OF COLORIMETRIC METHODS WITH SPECIAL REFERENCE TO INDIGO CARMINE AS A FUNCTIONAL TEST: A PRELIMINARY REPORT. | 1920 Feb |
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The use of indigo carmine for dye dilution curves. | 1955 Nov |
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Profound hypotension after an intradermal injection of indigo carmine for sentinel node mapping. | 2013 Mar |
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Clinical impact of dual red imaging in colorectal endoscopic submucosal dissection: a pilot study. | 2016 Sep |
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A Third Surgically Managed Ectopic Pregnancy after Two Salpingectomies Involving the Opposite Tube. | 2017 |
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The detection of sentinel lymph nodes in laparoscopic surgery for uterine cervical cancer using 99m-technetium-tin colloid, indocyanine green, and blue dye. | 2017 Mar |
Patents
Sample Use Guides
Indigotindisulfonic acid (Indigo Carmine) solution is injected either by the intravenous or intramuscular route, and its appearance at the ureteral orifices is watched with the cystoscope in place.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23341851
Human chondrocytes grown on 6-well plates to 80% subconfluence were incubated with different concentrations of indigotindisulfonic acid (1, 10 and 100% solution) for 5 and 10 minutes. Human chondrocytes treated with solutions of 100% solution showed increased number of cells with defect cell structure. Chondrocytes showed loss of cell contacts after an incubation time of 10 minutes as revealed by light microscopy.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:42:33 UTC 2023
by
admin
on
Fri Dec 15 15:42:33 UTC 2023
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Record UNII |
X7OI7JF73P
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Record Status |
Validated (UNII)
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Record Version |
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