Ambruticin is a natural polyketide isolated from the myxobacteria Sorangium cellulosum. Ambruticin possesses antifungal activity and works by interfering with the osmoregulatory system by activating fungal high osmolarity glycerol (HOG) pathway. This results in an accumulation of intracellular glycerol, which in turn causes water influx and swelling of the cell. This ultimately leads to cellular leakage and cell death. Although ambruticin appeared to be the only oral agent capable of eliciting a high order of biological cure against experimental coccidioidomycosis, research support was discontinued in 1977 because this antibiotic had limited activity against Candida albicans.