Details
Stereochemistry | ACHIRAL |
Molecular Formula | C9H10O4 |
Molecular Weight | 182.1737 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COc1cc(ccc1O)CC(=O)O
InChI
InChIKey=QRMZSPFSDQBLIX-UHFFFAOYSA-N
InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)
Molecular Formula | C9H10O4 |
Molecular Weight | 182.1737 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P00433 Gene ID: NA Gene Symbol: PRXC1A Target Organism: Armoracia rusticana (Horseradish) (Armoracia laphatifolia) Sources: https://www.ncbi.nlm.nih.gov/pubmed/5634544 |
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Target ID: Flucose oxidase, fungal Sources: https://www.ncbi.nlm.nih.gov/pubmed/5634544 |
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Target ID: CHEMBL3649 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5634544 |
PubMed
Title | Date | PubMed |
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Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. | 1999 May 7 |
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CSF studies in violent offenders. I. 5-HIAA as a negative and HVA as a positive predictor of psychopathy. | 2001 |
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Opposite genotype-dependent mesocorticolimbic dopamine response to stress. | 2001 |
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Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain. | 2001 |
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The differential effect of angiotensin II and angiotensin 1-7 on norepinephrine, epinephrine, and dopamine concentrations in rat hypothalamus: the involvement of angiotensin receptors. | 2001 Apr |
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Nitric oxide synthase inhibitors cause motor deficits in mice. | 2001 Apr |
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Oxalic acid stabilizes dopamine, serotonin, and their metabolites in automated liquid chromatography with electrochemical detection. | 2001 Apr 5 |
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Site-specific activation of dopamine and serotonin transmission by aniracetam in the mesocorticolimbic pathway of rats. | 2001 Apr 6 |
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[Value of 123I-MIBG scanning, neuron-specific enolase and serum ferritin in the diagnosis and follow-up of patients with neuroblastoma]. | 2001 Aug |
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Gender-dependent enhanced adult neurotoxic response to methamphetamine following fetal exposure to the drug. | 2001 Aug |
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A simple method to measure baseline occupancy of neostriatal dopamine D2 receptors by dopamine in vivo in healthy subjects. | 2001 Aug |
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Continuous phencyclidine treatment induces schizophrenia-like hyperreactivity of striatal dopamine release. | 2001 Aug |
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The cannabinoid CB(1) receptor antagonist SR141716A increases norepinephrine outflow in the rat anterior hypothalamus. | 2001 Aug 31 |
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Developmental changes in cerebrospinal fluid concentrations of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy. | 2001 Feb |
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Differentiation of disulfiram effects on central catecholamines and hepatic ethanol metabolism. | 2001 Feb |
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Evaluation of catecholamine metabolites, mIBG scan, and bone marrow cytology as response markers in stage 4 neuroblastoma. | 2001 Jan |
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Observation of untreated patients with neuroblastoma detected by mass screening: a "wait and see" pilot study. | 2001 Jan |
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Biphasic effects of selegiline on striatal dopamine: lack of effect on methamphetamine-induced dopamine depletion. | 2001 Jan |
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Striatal dopamine sensitization to D-amphetamine in periadolescent but not in adult rats. | 2001 Jan |
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CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome. | 2001 Jan |
|
The effects of water-odor preference conditioning in the preadolescent nucleus accumbens septi. | 2001 Jan |
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The central aromatic amino acid DOPA decarboxylase inhibitor, NSD-1015, does not inhibit L-DOPA-induced circling in unilateral 6-OHDA-lesioned-rats. | 2001 Jan |
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Significance of glutamate and dopamine neurons in the ventral pallidum in the expression of behavioral sensitization to amphetamine. | 2001 Jan 19 |
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Distal infantile neuroaxonal dystrophy--a new familial variant with perineuronal argyrophilic bodies. | 2001 Jul |
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Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties. | 2001 Jul |
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Biochemical and pathological study of endogenous 1-benzyl-1,2,3,4-tetrahydroisoquinoline-induced parkinsonism in the mouse. | 2001 Jul 13 |
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Motoric behavior in aged rats treated with GM1. | 2001 Jul 6 |
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Effects of repeated morphine treatment on metabolism of cerebral dopamine and serotonin in alcohol-preferring AA and alcohol-avoiding ANA rats. | 2001 Jul-Aug |
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Long term effects of Toki-shakuyaku-san on brain dopamine and nerve growth factor in olfactory-bulb-lesioned mice. | 2001 Jun |
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Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease. | 2001 Jun |
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A novel neurodevelopmental syndrome responsive to 5-hydroxytryptophan and carbidopa. | 2001 Jun |
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Dopaminergic changes in human brain following acute exposure to gamma-hydroxybutyrate. | 2001 Jun 12 |
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Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway? | 2001 Jun 15 |
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Oxygen inhalation enhances striatal dopamine metabolism and monoamineoxidase enzyme inhibition prevents it: a microdialysis study. | 2001 Jun 22 |
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Effect of embryonic knock-down of GABAA receptors on the levels of monoamines and their metabolites in the CNS of the mouse. | 2001 Jun 22 |
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Differential abnormalities in plasma 5-HIAA and platelet serotonin concentrations in violent suicide attempters: relationships with impulsivity and depression. | 2001 Jun 29 |
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3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose. | 2001 Mar |
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Increased extracellular DA and normal evoked DA release in the rat striatum after a partial lesion of the substantia nigra. | 2001 Mar 2 |
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[Involvement of dopaminergic systems in the functional specialization of brain areas during formation of aggressive and submissive behavior in mice]. | 2001 Mar-Apr |
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Chronic estrogen treatment replaces striatal dopaminergic function in ovariectomized rats. | 2001 May 11 |
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BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation. | 2001 May 18 |
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Nomifensine reveals age-related changes in K(+)-evoked striatal DA overflow in F344 rats. | 2001 May-Jun |
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Effect of clonazepam treatment on antipsychotic drug-induced Meige syndrome and changes in plasma levels of GABA, HVA, and MHPG during treatment. | 2001 Oct |
|
Effect of chronic protein restriction on motor co-ordination and brain neurotransmitters in albino rats. | 2001 Oct |
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Aging increases the susceptiblity to methamphetamine-induced dopaminergic neurotoxicity in rats: correlation with peroxynitrite production and hyperthermia. | 2001 Sep |
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Heart failure, aging, and renal synthesis of dopamine. | 2001 Sep |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 04:44:49 UTC 2021
by
admin
on
Sat Jun 26 04:44:49 UTC 2021
|
Record UNII |
X77S6GMS36
|
Record Status |
Validated (UNII)
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Record Version |
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X77S6GMS36
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M6049
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D006719
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HOMOVANILLIC ACID
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1738
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306-08-1
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206-176-7
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306-08-1
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PARENT -> CONSTITUENT ALWAYS PRESENT |
151.4% reaction on PG synthase w/10.0 mM conc. of compound
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PARENT -> METABOLITE |
IN-VIVO
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PARENT -> METABOLITE |
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