METHYLPREDNISOLONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H30O5
Molecular Weight	374.4706
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)C=CC(=O)C=C14

InChI

InChIKey=VHRSUDSXCMQTMA-PJHHCJLFSA-N

InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H30O5
Molecular Weight	374.4706
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.drugbank.ca/drugs/DB00959
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/pro/medrol.html

Methylprednisolone is a prednisolone derivative with similar anti-inflammatory and immunosuppressive action. It is adjunctive therapy for short-term administration in rheumatoid arthritis. It is indicated in the following conditions: endocrine disorders, rheumatic disorders, collagen diseases, allergic states etc. Methylprednisolone is marketed in the USA and Canada under the brand names Medrol and Solu-Medrol. Methylprednisolone is a GR receptor agonist.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Glucocorticoid receptor 173 Target ID: CHEMBL2034 Sources: http://www.drugbank.ca/drugs/DB00959	Agonist 2752	2.4 nM [EC50]
Glucocorticoid receptor 173 Target ID: CHEMBL2034 Sources: http://www.ampoule.org.hk/pdf/advantan.pdf	Agonist 2752
Serotonin 3 (5-HT3) receptor 59 Target ID: CHEMBL2111332 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15329590	Inhibitor 8504	1.07 nM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Congenital adrenal hyperplasia 62 Sources: https://www.drugs.com/pro/medrol.html	Primary	Approved 8583	MEDROL Approved Use INDICATIONS AND USAGE MEDROL Tablets are indicated in the following conditions: 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance). Congenital adrenal hyperplasia Nonsuppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis Acute and subacute bursitis Synovitis of osteoarthritis Acute nonspecific tenosynovitis Post-traumatic osteoarthritis Psoriatic arthritis Epicondylitis Acute gouty arthritis 3. Collagen Diseases During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus Systemic dermatomyositis (polymyositis) Acute rheumatic carditis 4. Dermatologic Diseases Bullous dermatitis herpetiformis Severe erythema multiforme (Stevens-Johnson syndrome) Severe seborrheic dermatitis Exfoliative dermatitis Mycosis fungoides Pemphigus Severe psoriasis 5. Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis Drug hypersensitivity reactions Serum sickness Contact dermatitis Bronchial asthma Atopic dermatitis 6. Ophthalmic Diseases Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: Allergic corneal marginal ulcers Herpes zoster ophthalmicus Anterior segment inflammation Diffuse posterior uveitis and choroiditis Sympathetic ophthalmia Keratitis Optic neuritis Allergic conjunctivitis Chorioretinitis Iritis and iridocyclitis 7. Respiratory Diseases Symptomatic sarcoidosis Berylliosis Loeffler's syndrome not manageable by other means Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy Aspiration pneumonitis 8. Hematologic Disorders Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia Erythroblastopenia (RBC anemia) Congenital (erythroid) hypoplastic anemia 9. Neoplastic Diseases For palliative management of: Leukemias and lymphomas in adults Acute leukemia of childhood 10. Edematous States To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. 11. Gastrointestinal Diseases To tide the patient over a critical period of the disease in: Ulcerative colitis Regional enteritis 12. Nervous System Acute exacerbations of multiple sclerosis 13. Miscellaneous Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy. Trichinosis with neurologic or myocardial involvement. Launch Date 1957
Rheumatoid arthritis 320 Sources: https://www.drugs.com/pro/medrol.html	Primary	Approved 8583	MEDROL Approved Use INDICATIONS AND USAGE MEDROL Tablets are indicated in the following conditions: 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance). Congenital adrenal hyperplasia Nonsuppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis Acute and subacute bursitis Synovitis of osteoarthritis Acute nonspecific tenosynovitis Post-traumatic osteoarthritis Psoriatic arthritis Epicondylitis Acute gouty arthritis 3. Collagen Diseases During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus Systemic dermatomyositis (polymyositis) Acute rheumatic carditis 4. Dermatologic Diseases Bullous dermatitis herpetiformis Severe erythema multiforme (Stevens-Johnson syndrome) Severe seborrheic dermatitis Exfoliative dermatitis Mycosis fungoides Pemphigus Severe psoriasis 5. Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis Drug hypersensitivity reactions Serum sickness Contact dermatitis Bronchial asthma Atopic dermatitis 6. Ophthalmic Diseases Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: Allergic corneal marginal ulcers Herpes zoster ophthalmicus Anterior segment inflammation Diffuse posterior uveitis and choroiditis Sympathetic ophthalmia Keratitis Optic neuritis Allergic conjunctivitis Chorioretinitis Iritis and iridocyclitis 7. Respiratory Diseases Symptomatic sarcoidosis Berylliosis Loeffler's syndrome not manageable by other means Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy Aspiration pneumonitis 8. Hematologic Disorders Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia Erythroblastopenia (RBC anemia) Congenital (erythroid) hypoplastic anemia 9. Neoplastic Diseases For palliative management of: Leukemias and lymphomas in adults Acute leukemia of childhood 10. Edematous States To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. 11. Gastrointestinal Diseases To tide the patient over a critical period of the disease in: Ulcerative colitis Regional enteritis 12. Nervous System Acute exacerbations of multiple sclerosis 13. Miscellaneous Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy. Trichinosis with neurologic or myocardial involvement. Launch Date 1957
Contact dermatitis 20 Sources: https://www.drugs.com/pro/medrol.html	Primary	Approved 8583	MEDROL Approved Use INDICATIONS AND USAGE MEDROL Tablets are indicated in the following conditions: 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance). Congenital adrenal hyperplasia Nonsuppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis Acute and subacute bursitis Synovitis of osteoarthritis Acute nonspecific tenosynovitis Post-traumatic osteoarthritis Psoriatic arthritis Epicondylitis Acute gouty arthritis 3. Collagen Diseases During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus Systemic dermatomyositis (polymyositis) Acute rheumatic carditis 4. Dermatologic Diseases Bullous dermatitis herpetiformis Severe erythema multiforme (Stevens-Johnson syndrome) Severe seborrheic dermatitis Exfoliative dermatitis Mycosis fungoides Pemphigus Severe psoriasis 5. Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis Drug hypersensitivity reactions Serum sickness Contact dermatitis Bronchial asthma Atopic dermatitis 6. Ophthalmic Diseases Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: Allergic corneal marginal ulcers Herpes zoster ophthalmicus Anterior segment inflammation Diffuse posterior uveitis and choroiditis Sympathetic ophthalmia Keratitis Optic neuritis Allergic conjunctivitis Chorioretinitis Iritis and iridocyclitis 7. Respiratory Diseases Symptomatic sarcoidosis Berylliosis Loeffler's syndrome not manageable by other means Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy Aspiration pneumonitis 8. Hematologic Disorders Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia Erythroblastopenia (RBC anemia) Congenital (erythroid) hypoplastic anemia 9. Neoplastic Diseases For palliative management of: Leukemias and lymphomas in adults Acute leukemia of childhood 10. Edematous States To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. 11. Gastrointestinal Diseases To tide the patient over a critical period of the disease in: Ulcerative colitis Regional enteritis 12. Nervous System Acute exacerbations of multiple sclerosis 13. Miscellaneous Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy. Trichinosis with neurologic or myocardial involvement. Launch Date 1957

C_max

Value	Dose	Co-administered	Analyte	Population
213 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/12174030	32 mg single, intravenous dose: 32 mg route of administration: Intravenous experiment type: SINGLE co-administered:		METHYLPREDNISOLONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
931 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/12174030	32 mg single, intravenous dose: 32 mg route of administration: Intravenous experiment type: SINGLE co-administered:		METHYLPREDNISOLONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.3 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/12174030	32 mg single, intravenous dose: 32 mg route of administration: Intravenous experiment type: SINGLE co-administered:		METHYLPREDNISOLONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
23% EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/?term=3732369			METHYLPREDNISOLONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
1000 mg/kg single, intravenous Highest studied dose Dose: 1000 mg/kg Route: intravenous Route: single Dose: 1000 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/8107739	unhealthy, 0-15 years Health Status: unhealthy Age Group: 0-15 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/8107739	Sources: https://pubmed.ncbi.nlm.nih.gov/8107739
1250 mg 1 times / day multiple, oral Highest studied dose Dose: 1250 mg, 1 times / day Route: oral Route: multiple Dose: 1250 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/30351511	unhealthy, 18–59 years Health Status: unhealthy Age Group: 18–59 years Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/30351511	Sources: https://pubmed.ncbi.nlm.nih.gov/30351511
120 mg 1 times / week multiple, intramuscular Highest studied dose Dose: 120 mg, 1 times / week Route: intramuscular Route: multiple Dose: 120 mg, 1 times / week Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/011757s119lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/011757s119lbl.pdf	Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/011757s119lbl.pdf

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946 inducer 1087

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
SLC10A2 9	11-beta-HSD2 48 11-beta-HSD1 33 AKR1C1 22	P-gp 301

Drug as perpetrator

Target	Modality	Activity
SLC10A2 9	inhibitor 4027 Sources: https://pubs.acs.org/doi/abs/10.1021/mp900163d Page: -	no
CYP3A4 2633	inducer 1966 Sources: https://link.springer.com/article/10.1007/s00204-008-0332-8 Page: -	yes
P-gp 1932	inducer 1966 Sources: https://www.sciencedirect.com/science/article/pii/S0378427411015943 Page: -	yes

Drug as victim

Target	Modality	Activity
11-beta-HSD1 33	substrate 4014 Sources: https://academic.oup.com/jcem/article/87/12/5695/2823639 Page: -	yes
11-beta-HSD2 48	substrate 4014 Sources: https://academic.oup.com/jcem/article/87/12/5695/2823639 Page: -	yes
AKR1C1 22	substrate 4014 Sources: http://epubs.surrey.ac.uk/855783/1/27606608.pdf Page: -	yes
CYP3A4 1946	substrate 4014 Sources: https://link.springer.com/article/10.1007/s00228-009-0653-4 Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-004636	http://www.3bsc.com/index/pro_info.php?id=26522
AA Blocks	AA003AUL	https://www.aablocks.com/goods/Goods/detail?id=AA003AUL
Aaron Chemicals	AR003BMD	http://www.aaronchem.com/83-43-2
AbMole Bioscience	M3468	http://www.abmole.com/products/methylprednisolone.html
Acadechem	ACDS-065513	http://www.acadechemical.com/product/140212
Achemtek	0104-014278	http://www.achemtek.com/83-43-2
Acorn PharmaTech	ACN-037579	http://www.acornpharmatech.com/
Acros Organics	AC338800010	https://www.fishersci.com/shop/products/6-methylprednisolone-acros-organics-1/AC338800010
Acros Organics	AC338800050	https://www.fishersci.com/shop/products/6-methylprednisolone-acros-organics-2/AC338800050
AEchem Scientific Corp., USA	AE1-016088	http://www.aechemsc.com/info_products/AE1-016088.php
AHH Chemical co.,ltd	MT-18718	http://www.ahhchemical.com/product/MT-18718.html
AK Scientific, Inc. (AKSCI)	H972	http://www.aksci.com/item_detail.php?cat=H972
Alfa Chemistry	ACM83432	https://www.alfa-chemistry.com/methylprednisolone-cas-83-43-2-item-106534.htm
Alsachim	3316	http://www.alsachim.com/product-C4602-glo.bal-view.html
ApexBio Technology	A4233	http://www.apexbt.com/methylprednisolone-16832.html
Aurora Fine Chemicals LLC	A17.894.462	http://online.aurorafinechemicals.com/info?ID=A17.894.462
AvaChem Scientific	2802	http://www.avachem.com/productSearch.asp?2802
Axon MedChem	2066	https://www.axonmedchem.com/product/2066
BioCrick	BCC2256	http://www.biocrick.com/Methylprednisolone-BCC2256.html
BioSynth	Q-201395	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/Q-201395.html
Chem Scene	CS-2246	http://www.chemscene.com/83-43-2.html
ChemMol	99160511	http://www.chemmol.com/chemmol/99160511.html
Chemspace	CSSB00000042994	https://chem-space.com/CSSB00000042994
Combi-Blocks	QH-6553	http://www.combi-blocks.com/cgi-bin/find.cgi?QH-6553
DC Chemicals	DCAPI1359	http://www.dcchemicals.com//product_show-Methylprednisolone.html
eNovation Chemicals	D628826	https://www.enovationchem.com/ProductDetails.asp?ProductID=D628826
eNovation Chemicals	D674504	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674504
eNovation Chemicals	D767281	https://www.enovationchem.com/ProductDetails.asp?ProductID=D767281
Glentham Life Sciences	GP2286	http://www.glentham.com/products/product/GP2286/
iChemical	EBD27626	http://www.ichemical.com/products/83-43-2.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network	LN00366059	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00366059
LGC Standards	DRE-C15141700	https://www.lgcstandards.com/US/en/p/DRE-C15141700
LGC Standards	DRE-XA15141700AL	https://www.lgcstandards.com/US/en/p/DRE-XA15141700AL
LGC Standards	LGCFOR0190.00	https://www.lgcstandards.com/US/en/p/LGCFOR0190.00
LGC Standards	MM0190.00-0250	https://www.lgcstandards.com/US/en/p/MM0190.00-0250
MedChem Express	HY-B0260	https://www.medchemexpress.com/methylprednisolone.html
OChem	4193	http://www.ocheminc.com/index.php?act=psearch&pid=010M591
Parchem	29400	http://www.parchem.com/chemical-supplier-distributor/Methylprednisolone-019400.aspx
Parchem	29401	http://www.parchem.com/chemical-supplier-distributor/Methylprednisolone-019401.aspx
Parchem	29406	http://www.parchem.com/chemical-supplier-distributor/Methylprednisolone-Sodium-Succinate-019406.aspx
Parchem	29407	http://www.parchem.com/chemical-supplier-distributor/Methylprednisolone-Sodium-Succinate-019407.aspx
Sigma-Aldrich	1435003_USP	https://www.sigmaaldrich.com/catalog/product/usp/1435003?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	46436_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/46436?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	BP248_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/bp248?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	M0639_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/m0639?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	M1750000_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/m1750000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S049856	http://www.sinfoobiotech.com/product/1053254
Smolecule	S535227	http://www.smolecule.com/products/s535227
TCI (Tokyo Chemical Industry)	M1665	http://www.tcichemicals.com/eshop/en/us/commodity/M1665/index.html
THE BioTek	bt-275679	https://www.thebiotek.com/product/inhibitors/bt-275679
Tocris	4819	https://www.tocris.com/products/methylprednisolone_4819

PubMed

Title	Date	PubMed
Use of epidural steroids after discectomy may predispose to infection.	2000 Feb 15	10707400
Acute quadriplegic myopathy in a 17-month-old boy.	2000 Jan	10641615
A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.	2000 Jun	10879669
[A senile case of acute necrotizing myopathy presenting prolonged severe muscle paralysis due to high dose glucocorticoid and muscle relaxant].	2000 Mar	10879076
Corticosteroids for acute severe asthma in hospitalised patients.	2001	11279726
Sensorineural hearing loss in conjunction with aortic insufficiency in systemic lupus erythematosus.	2001	11252692
The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).	2001	11178128
Initial remission-inducing effect of very low-dose cyclosporin monotherapy for minimal-change nephrotic syndrome in Japanese adults.	2001 Feb	11269678
Severe renal impairment in the case of classic polyarteritis nodosa.	2001 Feb	11261683
Three cases of C-ANCA-positive vasculitis treated with immunoadsorption: possible benefit in early treatment.	2001 Feb	11258615
Lupus nephritis in children: prognostic significance of clinicopathological findings.	2001 Feb	11244305
Effects of intraarticular glucocorticoids on macrophage infiltration and mediators of joint damage in osteoarthritis synovial membranes: findings in a double-blind, placebo-controlled study.	2001 Feb	11229465
Multiple arterial ectasias in patients with sarcoidosis and uveitis.	2001 Feb	11228299
[Evaluation of off-pump coronary artery bypass grafting based on systemic inflammatory response syndrome].	2001 Feb	11211761
Contact allergy to miripirium chloride in Depo-Medrol.	2001 Feb	11205399
[Is it useful to perform a (67)gallium scintigraphy in the follow-up of patients with gastric lymphoma?].	2001 Feb	11181327
Childhood bullous pemphigoid developed after the first vaccination.	2001 Feb	11174412
Early complications of high-dose methylprednisolone sodium succinate treatment in the follow-up of acute cervical spinal cord injury.	2001 Feb 15	11224891
Cytokine characteristics of jaundice in mouse liver.	2001 Feb 7	11161464
Pharmacoeconomic study of tacrolimus-based versus cyclosporine-based immunosuppressive therapy following liver transplantation.	2001 Feb-Mar	11267411
Standard cyclosporine A-based versus completely steroid-free FK506-based immunosuppression after liver transplantation.	2001 Feb-Mar	11267396
Daclizumab induction for primary kidney transplant recipients using tacrolimus, mycophenolate mofetil, and steroids as maintenance immunosuppression.	2001 Feb-Mar	11267169
Addition of steroids blocks the tolerogenic potential of donor-specific blood transfusion.	2001 Feb-Mar	11266868
Graft failure in a patient with systemic lupus erythematosus (SLE) treated with high-dose immunosuppression and autologous stem cell rescue.	2001 Jan	11281396
A three or more drug combination as effective therapy for moderate or severe chronic graft-versus-host disease.	2001 Jan	11244437
[Anesthetic management for mitral valve replacement in a patient with idiopathic hypereosinophilic syndrome].	2001 Jan	11211746
Pretreatment with FK506 improves survival rate and gas exchange in canine model of acute lung injury.	2001 Jan	11208629
Two cases of severe bronchopneumonia due to influenza A (H3N2) virus: detection of influenza virus gene using reverse transcription polymerase chain reaction.	2001 Jan	11201374
Preventive effects of lecithinized superoxide dismutase and methylprednisolone on spinal cord injury in rats: transcriptional regulation of inflammatory and neurotrophic genes.	2001 Jan	11200253
New treatment for postherpetic neuralgia.	2001 Jan	11198414
Effects of anti-inflammatory drugs on lipopolysaccharide-challenged and -unchallenged equine synovial explants.	2001 Jan	11197561
Severe arthralgia and myalgia due to high-dose methylprednisolone pulse therapy cured by potassium infusion in a patient with diffuse proliferative lupus nephritis.	2001 Jan	11174035
High-dose methylprednisolone treatment in experimental focal cerebral ischemia.	2001 Jan	11161604
Enhancement of goblet cell hyperplasia and airway hyperresponsiveness by salbutamol in a rat model of atopic asthma.	2001 Jan	11120899
Recurrent orbital inflammation from metastatic orbital carcinoid tumor.	2001 Mar	11281589
[Intramural hematoma of the large intestine caused by cytomegalovirus vasculitis in a patient with SLE].	2001 Mar	11280907
Lymph draining from foot joints in rheumatoid arthritis provides insight into local cytokine and chemokine production and transport to lymph nodes.	2001 Mar	11263768
The impact of attaining a minimal disease state after high-dose melphalan and autologous transplantation for multiple myeloma.	2001 Mar	11260088
Steroids for acute exacerbations of COPD : how long is enough?	2001 Mar	11243937
Regional trabecular bone matrix degeneration and osteocyte death in femora of glucocorticoid- treated rabbits.	2001 Mar	11181552
Intrathecal methylprednisolone for postherpetic neuralgia.	2001 Mar 29	11280323
[Comparison of two different treatments of lateral humeral epicondylitis--"tennis elbow". A randomized controlled trial].	2001 Mar 5	11257751

Patents

Sample Use Guides

In Vivo Use Guide

Each Medrol Tablet (methylprednisolone) for oral administration contains 2 mg, 4 mg, 8 mg, 16 mg or 32 mg of methylprednisolone. The initial dosage of Medrol Tablets may vary from 4 mg to 48 mg of methylprednisolone per day depending on the specific disease entity being treated.

Route of Administration: Other

In Vitro Use Guide

Treatment with methylprednisolone concentrations above 50 uM could ignificantly reduce the proliferation activity of human CLL cell line MEC-1 by 23.34%, 30.73%, 30.57% after 24 h, and 28.48%, 42.35%, 44.56% after 48 h respectively

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:46:52 GMT 2025` Edited by `admin` on `Mon Mar 31 17:46:52 GMT 2025`
Record UNII	X4W7ZR7023
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

METHYLPREDNISOLONE

Official Name

English

NEO-MEDROL COMPONENT METHYLPREDNISOLONE

Preferred Name

English

METHYLPREDNISOLONE HYDROGEN SUCCINATE IMPURITY A [EP IMPURITY]

Common Name

English

U-67,590A

Code

English

METHYLPREDNISOLONE [USP MONOGRAPH]

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 11,17,21-TRIHYDROXY-6-METHYL-, (6.ALPHA.,11.BETA.)-

Systematic Name

English

METHYLPREDNISOLONE [GREEN BOOK]

Common Name

English

METHYLPREDNISOLONE [EP MONOGRAPH]

Common Name

English

NSC-19987

Code

English

METHYLPREDNISOLONE [MI]

Common Name

English

11?,17,21-Trihydroxy-6?-methylpregna-1,4-diene-3,20-dione

Systematic Name

English

METHYLPREDNISOLONE [MART.]

Common Name

English

6-METHYL-PREDNISOLONE

Common Name

English

METHYLPREDNISOLONE [USP-RS]

Common Name

English

METHYLPREDNISOLONE [ORANGE BOOK]

Common Name

English

Methylprednisolone [WHO-DD]

Common Name

English

methylprednisolone [INN]

Common Name

English

METHYLPREDNISOLONE ACETATE IMPURITY B [EP IMPURITY]

Common Name

English

J3.872E

Code

English

METHYLPREDNISOLONE [JAN]

Common Name

English

MEDROL

Brand Name

English

6-METHYLPREDNISOLONE

Common Name

English

METHYLPREDNISOLONE [VANDF]

Common Name

English

METHYLPREDNISOLONE [HSDB]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH02AB04