Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 3ClH.HNO3 |
| Molecular Weight | 172.396 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.Cl.O[N+]([O-])=O
InChI
InChIKey=NICDRCVJGXLKSF-UHFFFAOYSA-N
InChI=1S/3ClH.HNO3/c;;;2-1(3)4/h3*1H;(H,2,3,4)
| Molecular Formula | HNO3 |
| Molecular Weight | 63.0128 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Nitrate ion (NO3 −) is found naturally in the environment and is an important plant nutrient. It is present at varying concentrations in all plants and is a part of the nitrogen cycle. Nitrate probably has a role in protecting the gastrointestinal tract against a variety of gastrointestinal pathogens, as nitrous oxide and acidified nitrite have antibacterial properties. Significant bacterial reduction of nitrate to nitrite does not normally take place in the stomach, except in individuals with low gastric acidity or with gastrointestinal infections. These may include individuals using antacids, particularly those that block acid secretion. Potassium nitrate is used as mild local desensitizer in toothpastes.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Proton translocation and the respiratory nitrate reductase of Escherichia coli. | 1975 Dec |
|
| Electrophysiologic properties of hydralazine in man. | 1980 Sep |
|
| Acquired methemoglobinemia and hemolytic anemia after usual doses of phenazopyridine. | 1982 Feb |
|
| [Acute and chronic cardiac decompensation: is vasodilator therapy useful?]. | 1982 Jan 14 |
|
| Calcium antagonists. | 1985 |
|
| Addition of nifedipine to maximal nitrate and beta-adrenoreceptor blocker therapy in coronary artery disease. | 1985 May 1 |
|
| Drug-induced torsade de pointes. | 1985 Nov-Dec |
|
| Nitrates in acute myocardial infarction. | 1987 |
|
| [Drug treatment of myocardial ischemia]. | 1991 |
|
| [Anti-angina therapy of coronary heart disease. Mono- or combination treatment]. | 1991 May |
|
| Transient reversal of blood flow in an internal thoracic artery to coronary artery graft during syncope. | 1994 Aug |
|
| Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells. | 1996 Feb 5 |
|
| Therapy of angina pectoris with long-acting nitrates: which agent and when? | 1996 May |
|
| Serum and tissue nitrate levels in murine visceral leishmaniasis correlate with parasite load but not with host protection. | 1997 Jul-Aug |
|
| Incidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: an ecological analysis. | 1997 May |
|
| Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: involvement of nitric oxide. | 1997 May |
|
| The assimilatory nitrate reductase from the phototrophic bacterium, Rhodobacter capsulatus E1F1, is a flavoprotein. | 1997 Sep 1 |
|
| Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP. | 1999 Jan 5 |
|
| [Upper gastrointestinal tract injury caused by ingestion of caustic substances]. | 2001 Apr |
|
| Respiratory tract responses to repeated inhalation of an oxidant and acid gas-particle air pollutant mixture. | 2001 Jun |
|
| Acute gastric perforation after acid ingestion. | 2002 Sep |
|
| Epidemiology of 377 patients with chemical burns in Guangdong province. | 2004 Sep |
|
| Rate and extent of percutaneous absorption of sertaconazole nitrate after topical administration. | 2005 |
|
| Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids. | 2005 Aug |
|
| [Clinical observation on acupuncture combined with medication for intractable angina pectoris]. | 2005 Feb |
|
| Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate. | 2005 Feb 1 |
|
| Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin. | 2005 Jan 10 |
|
| Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant. | 2005 Jul-Sep |
|
| Nitric acid-induced bronchiolitis in rats mimics childhood Bronchiolitis obliterans. | 2005 Nov-Dec |
|
| Cl- interference with the epithelial Na+ channel ENaC. | 2005 Sep 9 |
|
| Clinical diagnostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium. | 2006 |
|
| Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats. | 2006 Jul |
|
| Immune cell infiltration and broncovascular remodeling after nitric acid nasal instillation in a mouse bronchiolitis obliterans model. | 2006 Jul-Aug |
|
| Modifications of inflammatory pathways in rat intestine following chronic ingestion of depleted uranium. | 2007 Aug |
|
| Oxidative and nitrosative stress in acute ischaemic stroke. | 2007 Jan |
|
| Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes. | 2007 Oct |
|
| Serofendic acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection. | 2007 Winter |
|
| Acute lung injury after inhalation of nitric acid. | 2008 Dec |
|
| Synthesis, pharmacological activity and nitric oxide generation by nitrate derivatives of theophylline. | 2008 May |
|
| An unusual circumstance of internal chemical burn injury - a case report. | 2008 Oct |
|
| Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases. | 2008 Sep |
|
| Water disinfection by-products and pre-labor rupture of membranes. | 2008 Sep 1 |
|
| Management of unusually extensive esophagogastric corrosive injuries: emergency measures and gastric reconstruction. | 2009 May |
|
| The nitric acid burn trauma of the skin. | 2010 Apr |
|
| Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease. | 2010 Jan |
|
| Fatal pulmonary edema after acute occupational exposure to nitric acid. | 2010 Jul |
|
| Goitrogenic anions, thyroid-stimulating hormone, and thyroid hormone in infants. | 2010 Sep |
|
| Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test. | 2011 Jan |
|
| Fine particulate matter constituents and cardiopulmonary mortality in a heavily polluted Chinese city. | 2012 Mar |
|
| NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis. | 2014 |
Patents
| Substance Class |
Chemical
Created
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admin
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Edited
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| Record UNII |
X3TT5X989E
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| Record Status |
Validated (UNII)
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| Record Version |
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8007-56-5
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AQUA_REGIA
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X3TT5X989E
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X3TT5X989E
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90477010
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DTXSID50893666
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1537801
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m7966
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