DescriptionSources: https://www.drugs.com/pro/ergoloid.htmlCurator's Comment: description was created based on several sources, including
https://www.drugbank.ca/drugs/DB01049 | http://www.solutionspharmacyrx.com/drug-detail/3432 | https://www.ncbi.nlm.nih.gov/pubmed/32430 | https://www.ncbi.nlm.nih.gov/pubmed/4894
Sources: https://www.drugs.com/pro/ergoloid.html
Curator's Comment: description was created based on several sources, including
https://www.drugbank.ca/drugs/DB01049 | http://www.solutionspharmacyrx.com/drug-detail/3432 | https://www.ncbi.nlm.nih.gov/pubmed/32430 | https://www.ncbi.nlm.nih.gov/pubmed/4894
Ergoloid mesylates (USAN), co-dergocrine mesilate (BAN) or dihydroergotoxine mesylate, trade name Hydergine, is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids (dihydroergocristine, dihydroergocornine, and alpha- and beta-dihydroergocryptine). It was developed by Albert Hofmann (the inventor of LSD) for Sandoz (now part of Novartis). Ergoloid mesylates act centrally, decreasing vascular tone and slowing the heart rate, and acts peripherally to block alpha-receptors. One other possible mechanism is the effect of ergoloid mesylates on neuronal cell metabolism, resulting in improved oxygen uptake and cerebral metabolism, thereby normalizing depressed neurotransmitter levels. Ergoloid Mesylate may increase cerebral metabolism and blood flow. The role of this medication in the therapy of dementia is controversial. A recent controlled study in patients with Alzheimer's disease found that there was no advantage to the use of ergoloid mesylates compared to placebo, suggesting that ergoloid mesylates may lower scores on some cognitive and behavioral rating scales. Further study is needed to determine the risk-benefit profile of ergoloid mesylates in the treatment of dementia.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2095203 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4894 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | HYDERGINE Approved UseIndications and Usage. Treatment of age-related decline in mental capacity, primary progressive dementia, Alzheimer dementia, multi-infarct dementia and senile onset. Launch Date2.52201599E11 |
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Primary | HYDERGINE Approved UseIndications and Usage. Treatment of age-related decline in mental capacity, primary progressive dementia, Alzheimer dementia, multi-infarct dementia and senile onset. Launch Date2.52201599E11 |
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Primary | HYDERGINE Approved UseIndications and Usage. Treatment of age-related decline in mental capacity, primary progressive dementia, Alzheimer dementia, multi-infarct dementia and senile onset. Launch Date2.52201599E11 |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.solutionspharmacyrx.com/drug-detail/3432
PO/sublingual 1 to 2 mg 3 times daily (up to 12 mg/day has been used).
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/643906
Mouse C1300 neuroblastoma cells were culturcd in medium having a pH of 7.3-7.4 (regular medium) and in medium having a pH of 6.6-6.8 (low pH medium). Cells were treated with Hydergine (Ergoloid mesylates) in various concentrations (0.1-10mkg/ml) for 8 days, and at the end of this time cell viability, cell number, neurites formation and lipofusein pigment formation were assessed. Hydergine, betwen 0.1 and 3 mkg/ml, caused aconcentration-related decrease in pigment content. Hydergine also stimulated neurite formation in cells in regular pH medium and was slightly toxic to cells in low pH medium.
Substance Class |
Mixture
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C04AE51
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QC04AE01
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SUB13594MIG
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DB01049
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m4980
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Ergoloid
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CHEMBL2364968
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D004877
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