Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H19ClN4.ClH |
| Molecular Weight | 363.284 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.ClC1=CC=C(C=C1)N2CCN(CC3=CNC4=C3C=CC=N4)CC2
InChI
InChIKey=GFFJYISJZJIKAF-UHFFFAOYSA-N
InChI=1S/C18H19ClN4.ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;/h1-7,12H,8-11,13H2,(H,20,21);1H
| Molecular Formula | C18H19ClN4 |
| Molecular Weight | 326.823 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine. | 2001 Apr 12 |
|
| Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. | 2001 Jun 4 |
|
| Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors. | 2003 Jun |
|
| Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina. | 2003 Jun |
|
| Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice. | 2003 Jun 16 |
|
| Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in mice. | 2004 Oct |
|
| Regulation of working memory by dopamine D4 receptor in rats. | 2004 Sep |
|
| Dopamine D4 receptors inhibit depolarization-induced [3H]GABA release in the rat subthalamic nucleus. | 2004 Sep 13 |
|
| Tonic modulation of inhibition by dopamine D4 receptors in the rat hippocampus. | 2005 |
|
| 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. | 2005 Jul |
|
| A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein. | 2005 Jul |
|
| The combination of nicotine with the D2 antagonist raclopride or the weak D4 antagonist L-745,870 generates a clozapine-like facilitation of NMDA receptor-mediated neurotransmission in pyramidal cells of the rat medial prefrontal cortex. | 2005 Jun |
|
| D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD. | 2010 Jan |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 14:38:22 GMT 2023
by
admin
on
Sat Dec 16 14:38:22 GMT 2023
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| Record UNII |
X2UD7T27FU
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| Record Status |
Validated (UNII)
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| Record Version |
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11957618
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1173023-36-3
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DTXSID101016928
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X2UD7T27FU
Created by
admin on Sat Dec 16 14:38:22 GMT 2023 , Edited by admin on Sat Dec 16 14:38:22 GMT 2023
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PARENT -> SALT/SOLVATE |
