L-745870 HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H19ClN4.ClH
Molecular Weight	363.284
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.ClC1=CC=C(C=C1)N2CCN(CC3=CNC4=C3C=CC=N4)CC2

InChI

InChIKey=GFFJYISJZJIKAF-UHFFFAOYSA-N

InChI=1S/C18H19ClN4.ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;/h1-7,12H,8-11,13H2,(H,20,21);1H

HIDE SMILES / InChI

Molecular Formula	C18H19ClN4
Molecular Weight	326.823
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D4 receptor 71 Target ID: CHEMBL219 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9353380\|https://www.ncbi.nlm.nih.gov/pubmed/9400001	Antagonist 2778		1.0 nM [IC50]

PubMed

Title	Date	PubMed
Effects of the atypical neuroleptic clozapine on micturition parameters in anesthetized rats.	2001	11574938
Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors.	2003 Jun	12763098
Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina.	2003 Jun	12763097
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.	2005 Jul	15992586
A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein.	2005 Jul	15729293
Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum.	2006 May	16415089
PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain.	2006 Oct	17067298
A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.	2008 Jun	18423451
Dopamine D4 receptor antagonist L745,870 abolishes cognitive effects of intracerebroventricular angiotensin IV and des-Phe(6)-Ang IV in rats.	2009 Feb	18835699
Dopaminergic modulation of risk-based decision making.	2009 Feb	18668030

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:38:22 GMT 2023` Edited by `admin` on `Sat Dec 16 14:38:22 GMT 2023`
Record UNII	X2UD7T27FU
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

L-745870 HYDROCHLORIDE

Code

English

3-((4-(4-CHLOROPHENYL)-1-PIPERAZINYL)METHYL)-1H-PYRROLO(2,3-B)PYRIDINE HYDROCHLORIDE

Systematic Name

English

1H-PYRROLO(2,3-B)PYRIDINE, 3-((4-(4-CHLOROPHENYL)-1-PIPERAZINYL)METHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

Code System Code Type Description

PUBCHEM

11957618

Created by admin on Sat Dec 16 14:38:22 GMT 2023 , Edited by admin on Sat Dec 16 14:38:22 GMT 2023

PRIMARY

CAS

1173023-36-3

Created by admin on Sat Dec 16 14:38:22 GMT 2023 , Edited by admin on Sat Dec 16 14:38:22 GMT 2023

PRIMARY

EPA CompTox

DTXSID101016928

Created by admin on Sat Dec 16 14:38:22 GMT 2023 , Edited by admin on Sat Dec 16 14:38:22 GMT 2023

PRIMARY

FDA UNII

X2UD7T27FU

Created by admin on Sat Dec 16 14:38:22 GMT 2023 , Edited by admin on Sat Dec 16 14:38:22 GMT 2023

PRIMARY

Related Record Type Details


					J3OLN3XSX7

L-745870

PARENT -> SALT/SOLVATE