L-745870

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H19ClN4
Molecular Weight	326.823
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

ClC1=CC=C(C=C1)N2CCN(CC3=CNC4=C3C=CC=N4)CC2

InChI

InChIKey=OGJGQVFWEPNYSB-UHFFFAOYSA-N

InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)

HIDE SMILES / InChI

Molecular Formula	C18H19ClN4
Molecular Weight	326.823
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D4 receptor 76	Antagonist 2,849		1.0 nM [IC50]

PubMed

Show entries

Title	Date	PubMed
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.	1996 May 10	8642550
Effects of the atypical neuroleptic clozapine on micturition parameters in anesthetized rats.	2001	11574938
Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine.	2001 Apr 12	11312915
Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.	2001 Jun 4	11378358
Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex.	2002 Nov 1	12417643

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Patents

Substance Class	Chemical
Record UNII	J3OLN3XSX7
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

L-745870

Code

English

1H-PYRROLO(2,3-B)PYRIDINE, 3-((4-(4-CHLOROPHENYL)-1-PIPERAZINYL)METHYL)-

Preferred Name

English

3-((4-(4-CHLOROPHENYL)-1-PIPERAZINYL)METHYL)-1H-PYRROLO(2,3-B)PYRIDINE

Systematic Name

English

Showing 1 to 3 of 3 entries

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Code System

Code

Type

Description

EPA CompTox

DTXSID40415513

PRIMARY

WIKIPEDIA

L-745,870

PRIMARY

PUBCHEM

5311200

PRIMARY

CAS

158985-00-3

PRIMARY

FDA UNII

J3OLN3XSX7

PRIMARY

Showing 1 to 5 of 5 entries

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Related Record

Type

Details


					8H9TSV2PSX

L-745870 TRIHYDROCHLORIDE

SALT/SOLVATE -> PARENT


					X2UD7T27FU

L-745870 HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Showing 1 to 2 of 2 entries

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