MEPROSCILLARIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C31H44O8
Molecular Weight	544.6763
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 12
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@H]1[C@H](C)O[C@@H](O[C@H]2CC[C@]3(C)[C@H]4CC[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CCC3=C2)C6=COC(=O)C=C6)[C@H](O)[C@@H]1O

InChI

InChIKey=RKWPZPDLTYBKCL-RVZGXXANSA-N

InChI=1S/C31H44O8/c1-17-27(36-4)25(33)26(34)28(38-17)39-20-9-12-29(2)19(15-20)6-7-23-22(29)10-13-30(3)21(11-14-31(23,30)35)18-5-8-24(32)37-16-18/h5,8,15-17,20-23,25-28,33-35H,6-7,9-14H2,1-4H3/t17-,20-,21+,22-,23+,25-,26+,27-,28-,29-,30+,31-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C31H44O8
Molecular Weight	544.6763
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	12 / 12
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/348206 | https://www.ncbi.nlm.nih.gov/pubmed/6845784 | https://www.ncbi.nlm.nih.gov/pubmed/522817 | Seyffart, G. (2012) Drug Dosage in Renal Insufficiency, page 362, retrieved from: https://books.google.ru/books?id=OavnCAAAQBAJ

Meproscillarin is a semisynthetic glycoside for the therapy of cardiac insufficiency. Meproscillarin is a drug with a high bioavailability (about 70%). Meproscillarin is at the only non-renal eliminated, lipophilic and short half-life digitalis and is therefore an ideal, cardiac inotropic agent for use in renal insufficiency. Meproscillarin can be used therapeutically in patients with liver cirrhosis, because a toxic accumulation is not to be expected. The rate of side effects of meproscillarin corresponded to that of other cardiac glycosides.

Approval Year

Sample Use Guides

In Vivo Use Guide

2-3 tablets of 0.25 mg daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:36:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:36:18 GMT 2025`
Record UNII	WYR1723LO7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEPROSCILLARIN

Official Name

English

PROSCILLARIDIN-4-METHYL ETHER

Preferred Name

English

3.BETA.-((6-DEOXY-4-O-METHYL-.ALPHA.-L-MANNOPYRANOSYL)OXY)-14-HYDROXYBUFA-4,20,22-TRIENOLIDE

Common Name

English

Meproscillarin [WHO-DD]

Common Name

English

PROSCILLARIDIN-4-METHYL ETHER [MI]

Common Name

English

meproscillarin [INN]

Common Name

English

MEPROSCILLARIN [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78322