ISOTHIPENDYL

US Previously Marketed

First approved in 1957

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H19N3S
Molecular Weight	285.407
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CN1C2=CC=CC=C2SC3=CC=CN=C13)N(C)C

InChI

InChIKey=OQJBSDFFQWMKBQ-UHFFFAOYSA-N

InChI=1S/C16H19N3S/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19/h4-10,12H,11H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C16H19N3S
Molecular Weight	285.407
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.drugbank.ca/drugs/DB08802
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/isothipendyl.html | https://www.ncbi.nlm.nih.gov/pubmed/22677929 | https://www.ncbi.nlm.nih.gov/pubmed/13792589 | https://www.ncbi.nlm.nih.gov/pubmed/14157559

Isothipendyl is a first generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic. It is nowadays scarcely used in the first line relief of allergies due to the anticholinergic side effect of somnolence but does have some limited use through topical application in the relief of insect bites and related itching (pruritus).

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 316 Target ID: CHEMBL231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4150325	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 52 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14481215	Primary		Approved 8583	Calmogel Approved Use Unknown

Doses

Dose	Population	Adverse events
1 % single, topical Recommended Dose: 1 % Route: topical Route: single Dose: 1 % Sources: https://pubmed.ncbi.nlm.nih.gov/6138212	unhealthy, 41 Health Status: unhealthy Age Group: 41 Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/6138212	Disc. AE: Allergic contact dermatitis... AEs leading to discontinuation/dose reduction: Allergic contact dermatitis Sources: https://pubmed.ncbi.nlm.nih.gov/6138212
72 mg multiple, oral Studied dose Dose: 72 mg Route: oral Route: multiple Dose: 72 mg Sources: https://pubmed.ncbi.nlm.nih.gov/13792589	unhealthy Health Status: unhealthy Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13792589	Disc. AE: Weakness generalised... AEs leading to discontinuation/dose reduction: Weakness generalised (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/13792589

AEs

AE	Significance	Dose	Population
Allergic contact dermatitis	Disc. AE	1 % single, topical Recommended Dose: 1 % Route: topical Route: single Dose: 1 % Sources: https://pubmed.ncbi.nlm.nih.gov/6138212	unhealthy, 41 Health Status: unhealthy Age Group: 41 Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/6138212
Weakness generalised	1 patient Disc. AE	72 mg multiple, oral Studied dose Dose: 72 mg Route: oral Route: multiple Dose: 72 mg Sources: https://pubmed.ncbi.nlm.nih.gov/13792589	unhealthy Health Status: unhealthy Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/13792589

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY556280	https://www.001chemical.com/chem/482-15-5
3B Scientific (Wuhan) Corp	3B2-1237	http://www.3bsc.com/index/pro_info.php?id=54953
AHH Chemical co.,ltd	MT-52993	http://www.ahhchemical.com/product/MT-52993.html
Alfa Chemistry	482-15-5	https://www.alfa-chemistry.com/isothipendyl-cas-482-15-5-item-292149.htm
Clearsynth	CS-T-56921	https://www.clearsynth.com/en/CST56921.html
eNovation Chemicals	D674442	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674442
Finetech	FT-0670563	http://www.finetechnology-ind.com/prod/detail/pub/482-15-5.html
Molcore	MC556280	https://www.molcore.com/product/482-15-5
MuseChem	I007385	https://www.musechem.com/product/I007385.html
Smolecule	S530976	http://www.smolecule.com/products/s530976
THE BioTek	bt-270103	https://www.thebiotek.com/product/inhibitors/bt-270103
Yuhao Chemical	RT10332	http://www.chemyuhao.com/482-15-5.html

PubMed

Title	Date	PubMed
Bis[N,N-dimethyl-1-(10H-pyrido[3,2-b][1,4]benzothia-zin-10-yl)propan-2-aminium] tetrakis-(thio-cyanato-κN)cobaltate(II).	2010-06-16	21587702
Spectrophotometric studies on the investigation of chromium in environmental samples.	2003-01	14723280
Spectrophotometric determination of molybdenum(VI) using isothipendyl hydrochloride and pipazethate hydrochloride in alloy steels and soil samples.	2001-09	11708072
Phototoxic and photoprotective effects of topical isothipendyl.	1995-04	8546983

Patents

Sample Use Guides

In Vivo Use Guide

The dosage of isothipendyl in children was 6 to 8 mg. daily given as a syrup containing 2 mg. per teaspoonful. In adults the dosage varied from one 4 mg. tablet thrice daily to two 12 mg. sustained-action tablets thrice daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:20:14 GMT 2025` Edited by `admin` on `Mon Mar 31 19:20:14 GMT 2025`
Record UNII	WVZ7K9P0JY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISOTHIPENDYL

Official Name

English

ACTAPRONT

Preferred Name

English

D-201

Code

English

UDANTOL

Brand Name

English

ODANTOL

Brand Name

English

(±)-ISOTHIPENDYL

Common Name

English

ISOTHIPENDYL [MI]

Common Name

English

isothipendyl [INN]

Common Name

English

DIMETHYLAMINOISOPROPYLAZAPHENOTHIAZINE

Systematic Name

English

10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-ETHANAMINE, N,N,.ALPHA.-TRIMETHYL-

Systematic Name

English

10-(2-DIMETHYLAMINOPROPYL)-10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE

Systematic Name

English

10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE, 10-(2-(DIMETHYLAMINO)PROPYL)-

Systematic Name

English

Isothipendyl [WHO-DD]

Common Name

English

N-DIMETHYLAMINOISOPROPYLTHIOPHENYLPYRIDYLAMINE

Systematic Name

English

AY-56012

Code

English

Classification Tree Code System Code

WHO-ATC

D04AA22