DIOXOLANE T

CC1=CN([C@H]2CO[C@@H](CO)O2)C(=O)NC1=O

InChIKey=BCAWWPAPHSAUQZ-RNFRBKRXSA-N

InChI=1S/C9H12N2O5/c1-5-2-11(9(14)10-8(5)13)6-4-15-7(3-12)16-6/h2,6-7,12H,3-4H2,1H3,(H,10,13,14)/t6-,7-/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

PubMed

Title	Date	PubMed
Phosphoramidate prodrugs of (-)-β-D-(2R,4R)-dioxolane-thymine (DOT) as potent anti-HIV agents.	2012-05-14	22358223
5'-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies.	2009-02-01	19153047
Mechanism of action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl) thymine as an anti-HIV agent.	2007	17542153
Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.	2006-04-01	16314108
Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism.	2005-06-16	15943470
Molecular mechanism of dioxolane nucleosides against 3TC resistant M184V mutant HIV.	2004-07	15196815
Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.	1992-05-29	1597854

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:59:49 GMT 2025` Edited by `admin` on `Mon Mar 31 18:59:49 GMT 2025`
Record UNII	WT6GZM4YA8
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

DIOXOLANE THYMINE NUCLEOSIDE

Preferred Name

English

DIOXOLANE T

Common Name

English

2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL)-5-METHYL-, (2R-CIS)-

Systematic Name

English

DOT

Common Name

English

Code System Code Type Description

PUBCHEM

451593

Created by admin on Mon Mar 31 18:59:49 GMT 2025 , Edited by admin on Mon Mar 31 18:59:49 GMT 2025

PRIMARY

CAS

136982-89-3

Created by admin on Mon Mar 31 18:59:49 GMT 2025 , Edited by admin on Mon Mar 31 18:59:49 GMT 2025

PRIMARY

FDA UNII

WT6GZM4YA8

Created by admin on Mon Mar 31 18:59:49 GMT 2025 , Edited by admin on Mon Mar 31 18:59:49 GMT 2025

PRIMARY

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