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LARONIDASE
WP58SVM6R4
US Approved Rx (2003)
First approved in 2003
General
Record Details
Names
15
Classification
8
Identifiers
15
Subunits
1
Glycosylation
6
Active Moiety
1
Characteristic Attributes
4
LARONIDASE
WP58SVM6R4
US Approved Rx (2003)
First approved in 2003
General
Approval Year
2003
176
Record Details
Substance Class
Protein
Protein Type
ENZYME
Protein Sub Type
IDURONIDASE
Sequence Origin
HUMAN
Sequence Type
COMPLETE
Record UNII
WP58SVM6R4
Record Status
Validated (UNII)
Record Version
23
22
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20
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18
17
16
15
14
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11
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9
8
7
6
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4
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1
Names
15
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entries
Name
Type
Language
Name
Type
Language
LARONIDASE
Official Name
English
IDURONIDASE, .ALPHA.-L-(8-HISTIDINE) (HUMAN)
Common Name
English
ALRONIDASE
Common Name
English
LARONIDASE [PURPLE BOOK CDER]
Common Name
English
LARONIDASE [JAN]
Common Name
English
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1
2
3
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Classification
8
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Classification Tree
Code System
Code
Classification Tree
Code System
Code
Glucosidases
Chemical Ingredients
[Chemical/Ingredient]
Enzymes and Coenzymes
[Chemical/Ingredient]
Enzymes
[Chemical/Ingredient]
Hydrolases
[Chemical/Ingredient]
Glycoside Hydrolases
[Chemical/Ingredient]
Glucosidases
[Chemical/Ingredient]
alpha-Glucosidases
[Chemical/Ingredient]
NDF-RT
N0000167711
Established Pharmacologic Class
Established Pharmacologic Class
[EPC]
Hydrolytic Lysosomal Glycosaminoglycan-specific Enzyme
[EPC]
NDF-RT
N0000175823
Enzymes
ATC
ALIMENTARY TRACT AND METABOLISM
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Enzymes
laronidase
WHO-ATC
A16AB05
Enzymes
VATC
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Enzymes
laronidase
WHO-VATC
QA16AB05
MUCOPOLYSACCHARIDOSES
EMA EPAR
SKIN AND CONNECTIVE TISSUE DISEASES
CONNECTIVE TISSUE DISEASES
MUCINOSES
MUCOPOLYSACCHARIDOSES
MUCOPOLYSACCHARIDOSIS I
EMA ASSESSMENT REPORTS
ALDURAZYME (AUTHOURIZED: MUCOPOLYSACCHARIDOSIS I)
Showing 1 to 5 of 8 entries
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Identifiers
15
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entries
Code System
Code
Type
Description
Code System
Code
Type
Description
USAN
LL-41
PRIMARY
EVMPD
SUB20048
PRIMARY
SMS_ID
100000089543
PRIMARY
DRUG BANK
DB00090
PRIMARY
MERCK INDEX
m6205
PRIMARY
Merck Index
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Subunits
1
Subunit 0
>SUBUNIT_0
Glycosylation
6
Glycosylation Type
MAMMALIAN
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Glycosylation Link Type
Site
Glycosylation Link Type
Site
N
1_85
N
1_165
N
1_311
N
1_357
N
1_390
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
WP58SVM6R4
LARONIDASE
ACTIVE MOIETY
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Characteristic Attributes
4
Name
Property Type
Amount
Referenced Substance
Defining
Parameters
References
MOL_WEIGHT
CHEMICAL
83000 Da (average)
Volume of Distribution
PHARMACOKINETIC
[0.24 to 0.6] Liters/Kilogram (average)
Biological Half-life
PHARMACOKINETIC
[1.5 to 3.6] hours (average)
Molecular Formula
CHEMICAL
ESTIMATED
C3169H4839N901O884S12
