OFORNINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H19N3O
Molecular Weight	281.3523
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(N1CCCCC1)C2=CC=CC=C2NC3=CC=NC=C3

InChI

InChIKey=YMODINPJYNHPTM-UHFFFAOYSA-N

InChI=1S/C17H19N3O/c21-17(20-12-4-1-5-13-20)15-6-2-3-7-16(15)19-14-8-10-18-11-9-14/h2-3,6-11H,1,4-5,12-13H2,(H,18,19)

HIDE SMILES / InChI

Molecular Formula	C17H19N3O
Molecular Weight	281.3523
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://doi.org/10.1002/ddr.430200303

Ofornine is a vasodilator with antihypertensive activity. Experiments on rats have shown that ofornine reduced spontaneously hypertensive (SH) blood pressure through vasodilating and presynaptic adrenolytic activities, and that a dopaminergic mechanism may be involved. Information about the current use of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Synthesis of Ofornine mimics from natural product l-vasicine as anti-hypertensive agents.	2017-02-15	28110819

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:46:28 GMT 2025` Edited by `admin` on `Wed Apr 02 08:46:28 GMT 2025`
Record UNII	WK1LBP1F3L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OFORNINE

Official Name

English

WIN 48,049

Preferred Name

English

1-(N-4-Pyridylanthraniloyl)piperidine

Systematic Name

English

OFORNINE [USAN]

Common Name

English

ofornine [INN]

Common Name

English

PIPERIDINE, 1-(2-(4-PYRIDINYLAMINO)BENZOYL)-

Systematic Name

English

WIN-48049

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C270