Senacnagene Enfaleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 10:22:36 GMT 2025` Edited by `admin` on `Wed Apr 02 10:22:36 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cells
Fraction Name	cd56 enriched, cd3- natural killer cells
Record UNII	WHJ747UHJ8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Senacnagene Enfaleucel

Official Name

English

allogeneic natural killer (NK) cells derived from peripheral blood mononuclear cells (PBMC) obtained by leukapheresis from healthy donors, transduced with a replication deficient murine stem cell virus (MSCV) derived ?-retroviral vector encoding (i) an a

Preferred Name

English

senacnagene enfaleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

WHJ747UHJ8

Created by admin on Wed Apr 02 10:22:37 GMT 2025 , Edited by admin on Wed Apr 02 10:22:37 GMT 2025

PRIMARY

NCI_THESAURUS

C211714

Created by admin on Wed Apr 02 10:22:37 GMT 2025 , Edited by admin on Wed Apr 02 10:22:37 GMT 2025

PRIMARY

INN

13218

Created by admin on Wed Apr 02 10:22:37 GMT 2025 , Edited by admin on Wed Apr 02 10:22:37 GMT 2025

PRIMARY

Related Record Type Details


					WHJ747UHJ8

Senacnagene Enfaleucel

ACTIVE MOIETY

Comments:

NKX101 cytotoxicity relative to non-engineered NK cells was significantly enhanced against hematologic and solid tumor cell lines.

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
CULTURE	EXPANSION			UNSPECIFIED SUBSTANCE	4e9dace8
RETROVIRAL TRANSFECTION		BIOLOGICAL		Senacnagene enfaleucel murine stem cell virus (MSCV) derived ?-retroviral vector	S3C9FN8DNQ