ETOMIDOLINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C23H29N3O2
Molecular Weight	379.4953
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1C(NC2=CC=C(OCCN3CCCCC3)C=C2)C4=CC=CC=C4C1=O

InChI

InChIKey=ITIONVBQFUNVJV-UHFFFAOYSA-N

InChI=1S/C23H29N3O2/c1-2-26-22(20-8-4-5-9-21(20)23(26)27)24-18-10-12-19(13-11-18)28-17-16-25-14-6-3-7-15-25/h4-5,8-13,22,24H,2-3,6-7,14-17H2,1H3

HIDE SMILES / InChI

Molecular Formula	C23H29N3O2
Molecular Weight	379.4953
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/6273622

Etomidoline is a synthetic antispasmodic that seems to have an action similar to benactyzine.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
[Endoscopic evaluation of the etomidoline effect on gastric motility].	1976 Sep-Oct	1005295
[Characteristic effect of etomidoline on contractile activity in the gastrointestinal tract in conscious dogs (author's transl)].	1978 Aug	722958
[Simultaneous observation of gastric acid secretion and antral motility. Comparative study of the action of 2 synthetic anticholinergics].	1979 Nov	317726

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Guinea pig ileum was incubated with different concentrations of etomidoline (from 10(-7) to 10(-4) M) and its effect on ACh contraction curves was studied. 3*10(-4) M of the drug significantly restricted the elevation of cyclic AMP level induced by Ba(II).

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:58:20 GMT 2023` Edited by `admin` on `Sat Dec 16 17:58:20 GMT 2023`
Record UNII	WFS7G78GYJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETOMIDOLINE

Official Name

English

etomidoline [INN]

Common Name

English

ETOMIDOLINE [MI]

Common Name

English

AMIDOLINE

Common Name

English

ETOMIDOLINE [JAN]

Common Name

English

SMEDOLIN

Brand Name

English

1H-ISOINDOL-1-ONE, 2-ETHYL-2,3-DIHYDRO-3-((4-(2-(1-PIPERIDINYL)ETHOXY)PHENYL)AMINO)-

Systematic Name

English

K-2680

Code

English

Etomidoline [WHO-DD]

Common Name

English

ETOMIDOLINE [MART.]

Common Name

English

NONSPA

Brand Name

English

2-ETHYL-3-(.BETA.-PIPERIDINO-P-PHENETIDINO)PHTHALIMIDINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29696