ETOMIDOLINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C23H29N3O2
Molecular Weight	379.4953
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1C(NC2=CC=C(OCCN3CCCCC3)C=C2)C4=CC=CC=C4C1=O

InChI

InChIKey=ITIONVBQFUNVJV-UHFFFAOYSA-N

InChI=1S/C23H29N3O2/c1-2-26-22(20-8-4-5-9-21(20)23(26)27)24-18-10-12-19(13-11-18)28-17-16-25-14-6-3-7-15-25/h4-5,8-13,22,24H,2-3,6-7,14-17H2,1H3

HIDE SMILES / InChI

Molecular Formula	C23H29N3O2
Molecular Weight	379.4953
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/6273622

Etomidoline is a synthetic antispasmodic that seems to have an action similar to benactyzine.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Comparison of effects of smooth muscle relaxing drugs in intestinal smooth muscle of guinea pig.	1983-05	6620119
Smooth muscle relaxing drugs and guinea pig ileum.	1981-04	6273622
[Simultaneous observation of gastric acid secretion and antral motility. Comparative study of the action of 2 synthetic anticholinergics].	1979-11	317726
[Characteristic effect of etomidoline on contractile activity in the gastrointestinal tract in conscious dogs (author's transl)].	1978-08	722958
[Endoscopic evaluation of the etomidoline effect on gastric motility].	1976-09-01	1005295

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Guinea pig ileum was incubated with different concentrations of etomidoline (from 10(-7) to 10(-4) M) and its effect on ACh contraction curves was studied. 3*10(-4) M of the drug significantly restricted the elevation of cyclic AMP level induced by Ba(II).

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:53:17 GMT 2025` Edited by `admin` on `Wed Apr 02 09:53:17 GMT 2025`
Record UNII	WFS7G78GYJ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ETOMIDOLINE

Official Name

English

NONSPA

Preferred Name

English

etomidoline [INN]

Common Name

English

ETOMIDOLINE [MI]

Common Name

English

AMIDOLINE

Common Name

English

ETOMIDOLINE [JAN]

Common Name

English

SMEDOLIN

Brand Name

English

1H-ISOINDOL-1-ONE, 2-ETHYL-2,3-DIHYDRO-3-((4-(2-(1-PIPERIDINYL)ETHOXY)PHENYL)AMINO)-

Systematic Name

English

K-2680

Code

English

Etomidoline [WHO-DD]

Common Name

English

ETOMIDOLINE [MART.]

Common Name

English

2-ETHYL-3-(.BETA.-PIPERIDINO-P-PHENETIDINO)PHTHALIMIDINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29696