Zovostotug

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:20:58 GMT 2025` Edited by `admin` on `Wed Apr 02 13:20:58 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	WCK9537JXW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Zovostotug

Official Name

English

Immunoglobulin G1, anti-(human CD163 antigen) (human monoclonal OR2805 ?1-chain), disulfide with human monoclonal OR2805 ?-chain, dimer

Preferred Name

English

zovostotug [INN]

Common Name

English

Code System Code Type Description

INN

12594

Created by admin on Wed Apr 02 13:20:58 GMT 2025 , Edited by admin on Wed Apr 02 13:20:58 GMT 2025

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FDA UNII

WCK9537JXW

Created by admin on Wed Apr 02 13:20:58 GMT 2025 , Edited by admin on Wed Apr 02 13:20:58 GMT 2025

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CAS

2756228-84-7

Created by admin on Wed Apr 02 13:20:58 GMT 2025 , Edited by admin on Wed Apr 02 13:20:58 GMT 2025

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SMS_ID

300000048121

Created by admin on Wed Apr 02 13:20:58 GMT 2025 , Edited by admin on Wed Apr 02 13:20:58 GMT 2025

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NCI_THESAURUS

C199138

Created by admin on Wed Apr 02 13:20:58 GMT 2025 , Edited by admin on Wed Apr 02 13:20:58 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_160	2_216
2_236	4_215
2_277	2_337
1_160	1_216
2_383	2_441
3_23	3_88
3_135	3_195
4_23	4_88
4_135	4_195
1_236	3_215
1_242	2_242
1_245	2_245
1_277	1_337
1_383	1_441

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_313
N	2_313

Related Record Type Details


					WCK9537JXW

ACTIVE MOIETY

Comments:

OR2805 binds to CD163 while also engaging an Fc receptor (FcR) on the same M2 macrophages, resulting in reprogramming of M2 macrophages and the loss of M2 cell-mediated immune-suppression.

Interaction Type:

PRECLINICAL

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_463] [2_463]	C-TERMINUS	K	Amount:	LYSINE	K3Z4F929H6
AMINO ACID REMOVAL	[3_9] [4_9]	N-TERMINUS	S	Amount:	SERINE	452VLY9402

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL