SP-420

Investigational

COCCOCCOC1=CC(O)=C(C=C1)C2=N[C@](C)(CS2)C(O)=O

InChIKey=YASYAEVZKXPYIZ-MRXNPFEDSA-N

InChI=1S/C16H21NO6S/c1-16(15(19)20)10-24-14(17-16)12-4-3-11(9-13(12)18)23-8-7-22-6-5-21-2/h3-4,9,18H,5-8,10H2,1-2H3,(H,19,20)/t16-/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

SP-420 is iron chelator developed by University Of Florida Research Foundation for the treatment of iron overload disease

Targets

Primary Target	Pharmacology	Condition	Potency
Iron(III) ion 1 Target ID: Iron(III) ion Sources: https://www.ncbi.nlm.nih.gov/pubmed/20232803	Chelating Agent 142

Conditions

Condition	Modality	Targets	Highest Phase	Product
Beta-thalassemia 7 Sources: https://clinicaltrials.gov/ct2/show/NCT02274233	Primary		Phase I 428	Unknown Approved Use Unknown
Iron overload 4 Sources: https://clinicaltrials.gov/ct2/show/NCT02274233	Primary		Phase I 428	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
The impact of polyether chain length on the iron clearing efficiency and physiochemical properties of desferrithiocin analogues.	2010 Apr 8	20232803

Patents

In Vivo Use Guide

1.5-24 mg/kg SP-420 once daily for 14 days

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:40:46 GMT 2023` Edited by `admin` on `Sat Dec 16 09:40:46 GMT 2023`
Record UNII	WBX54NZ436
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

SP-420

Code

English

4-THIAZOLECARBOXYLIC ACID, 4,5-DIHYDRO-2-(2-HYDROXY-4-(2-(2-METHOXYETHOXY)ETHOXY)PHENYL)-4-METHYL-, (4S)-

Systematic Name

English

(4S)-4,5-DIHYDRO-2-(2-HYDROXY-4-(2-(2-METHOXYETHOXY)ETHOXY)PHENYL)-4-METHYL-4-THIAZOLECARBOXYLIC ACID

Systematic Name

English

Code System Code Type Description

NCI_THESAURUS

C178064