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Details

Stereochemistry RACEMIC
Molecular Formula C19H20N4O2
Molecular Weight 336.3877
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RISPENZEPINE

SMILES

CN1CCCC(C1)C(=O)N2C3=CC=CC=C3NC(=O)C4=CC=CN=C24

InChI

InChIKey=LPLNSPKKMWHFAU-UHFFFAOYSA-N
InChI=1S/C19H20N4O2/c1-22-11-5-6-13(12-22)19(25)23-16-9-3-2-8-15(16)21-18(24)14-7-4-10-20-17(14)23/h2-4,7-10,13H,5-6,11-12H2,1H3,(H,21,24)

HIDE SMILES / InChI

Molecular Formula C19H20N4O2
Molecular Weight 336.3877
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Rispenzepine (DF 594) is a muscarinic receptor antagonist. Rispenzepine has high affinity for intestinal muscarinic receptors, with preferential action at M1 and M3 receptor subtypes. This drug shows potent inhibitory effects on intestinal motility. In guinea pigs, rispenzepine significantly increases acetylcholine release in the trachea. A phase II study to test efficacy in asthma patients has been discontinued.

Originator

Approval Year

Substance Class Chemical
Created
by admin
on Fri Dec 15 17:24:34 GMT 2023
Edited
by admin
on Fri Dec 15 17:24:34 GMT 2023
Record UNII
W99LLM73R7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RISPENZEPINE
INN  
INN  
Official Name English
rispenzepine [INN]
Common Name English
5H-PYRIDO(2,3-B)(1,5)BENZODIAZEPIN-5-ONE, 6,11-DIHYDRO-11-((1-METHYL-3-PIPERIDINYL)CARBONYL)-
Systematic Name English
6,11-DIHYDRO-11-((1-METHYL-3-PIPERIDINYL)CARBONYL)-5H-PYRIDO(2,3-B)(1,5)BENZODIAZEPIN-5-ONE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29698
Created by admin on Fri Dec 15 17:24:34 GMT 2023 , Edited by admin on Fri Dec 15 17:24:34 GMT 2023
Code System Code Type Description
CAS
96449-05-7
Created by admin on Fri Dec 15 17:24:34 GMT 2023 , Edited by admin on Fri Dec 15 17:24:34 GMT 2023
PRIMARY
FDA UNII
W99LLM73R7
Created by admin on Fri Dec 15 17:24:34 GMT 2023 , Edited by admin on Fri Dec 15 17:24:34 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106612
Created by admin on Fri Dec 15 17:24:34 GMT 2023 , Edited by admin on Fri Dec 15 17:24:34 GMT 2023
PRIMARY
EVMPD
SUB10334MIG
Created by admin on Fri Dec 15 17:24:34 GMT 2023 , Edited by admin on Fri Dec 15 17:24:34 GMT 2023
PRIMARY
SMS_ID
100000080572
Created by admin on Fri Dec 15 17:24:34 GMT 2023 , Edited by admin on Fri Dec 15 17:24:34 GMT 2023
PRIMARY
PUBCHEM
129505
Created by admin on Fri Dec 15 17:24:34 GMT 2023 , Edited by admin on Fri Dec 15 17:24:34 GMT 2023
PRIMARY
INN
6521
Created by admin on Fri Dec 15 17:24:34 GMT 2023 , Edited by admin on Fri Dec 15 17:24:34 GMT 2023
PRIMARY
NCI_THESAURUS
C74175
Created by admin on Fri Dec 15 17:24:34 GMT 2023 , Edited by admin on Fri Dec 15 17:24:34 GMT 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY