Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H19NO5 |
| Molecular Weight | 341.3579 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(C=C1)C(=CN2)C(=O)C3=CC(OC)=C(OC)C(OC)=C3
InChI
InChIKey=UZJVBXKFBQNDTQ-UHFFFAOYSA-N
InChI=1S/C19H19NO5/c1-22-12-5-6-13-14(10-20-15(13)9-12)18(21)11-7-16(23-2)19(25-4)17(8-11)24-3/h5-10,20H,1-4H3
| Molecular Formula | C19H19NO5 |
| Molecular Weight | 341.3579 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
BPR0L075 [6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole] is an anti-microtubule drug and is a promising anticancer compound with antimitotic activity. It has potential for management of various malignancies, particularly for patients with drug resistance. BPR0L075 inhibits tubulin polymerization through binding to the colchicine-binding site of tubulin.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075. | 2010-07 |
|
| Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach. | 2009-08-13 |
|
| Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers. | 2009-07-03 |
|
| Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents. | 2008-08-01 |
|
| Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes. | 2007-07 |
|
| Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: application to a pharmacokinetic study. | 2007-02-01 |
|
| Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents. | 2006-10 |
|
| BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. | 2004-07-01 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:09:51 GMT 2025
by
admin
on
Mon Mar 31 21:09:51 GMT 2025
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| Record UNII |
W918223VQ6
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
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FDA ORPHAN DRUG |
524516
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613679-11-1
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10359957
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DTXSID20210285
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W918223VQ6
Created by
admin on Mon Mar 31 21:09:51 GMT 2025 , Edited by admin on Mon Mar 31 21:09:51 GMT 2025
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