Details
Stereochemistry | ACHIRAL |
Molecular Formula | C19H19NO5 |
Molecular Weight | 341.3579 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C2C(NC=C2C(=O)C3=CC(OC)=C(OC)C(OC)=C3)=C1
InChI
InChIKey=UZJVBXKFBQNDTQ-UHFFFAOYSA-N
InChI=1S/C19H19NO5/c1-22-12-5-6-13-14(10-20-15(13)9-12)18(21)11-7-16(23-2)19(25-4)17(8-11)24-3/h5-10,20H,1-4H3
Molecular Formula | C19H19NO5 |
Molecular Weight | 341.3579 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
BPR0L075 [6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole] is an anti-microtubule drug and is a promising anticancer compound with antimitotic activity. It has potential for management of various malignancies, particularly for patients with drug resistance. BPR0L075 inhibits tubulin polymerization through binding to the colchicine-binding site of tubulin.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. | 2004 Jul 1 |
|
Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents. | 2006 Oct |
|
Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes. | 2007 Jul |
|
Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents. | 2008 Aug 1 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 02:11:00 GMT 2023
by
admin
on
Sat Dec 16 02:11:00 GMT 2023
|
Record UNII |
W918223VQ6
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
FDA ORPHAN DRUG |
524516
Created by
admin on Sat Dec 16 02:11:00 GMT 2023 , Edited by admin on Sat Dec 16 02:11:00 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
613679-11-1
Created by
admin on Sat Dec 16 02:11:00 GMT 2023 , Edited by admin on Sat Dec 16 02:11:00 GMT 2023
|
PRIMARY | |||
|
10359957
Created by
admin on Sat Dec 16 02:11:00 GMT 2023 , Edited by admin on Sat Dec 16 02:11:00 GMT 2023
|
PRIMARY | |||
|
DTXSID20210285
Created by
admin on Sat Dec 16 02:11:00 GMT 2023 , Edited by admin on Sat Dec 16 02:11:00 GMT 2023
|
PRIMARY | |||
|
W918223VQ6
Created by
admin on Sat Dec 16 02:11:00 GMT 2023 , Edited by admin on Sat Dec 16 02:11:00 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |