Inaticabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 17:18:34 GMT 2025` Edited by `admin` on `Wed Apr 02 17:18:34 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	enriched for cd4/cd8 t cells
Record UNII	W8VE86L4EU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector, encoding a chimeric antigen receptor targeting CD19. The expressed transgene comprises a C

Preferred Name

English

Inaticabtagene Autoleucel

Official Name

English

Inaticabtagene autoleucel [WHO-DD]

Common Name

English

Inaticabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C199061

Created by admin on Wed Apr 02 17:18:34 GMT 2025 , Edited by admin on Wed Apr 02 17:18:34 GMT 2025

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SMS_ID

300000050060

Created by admin on Wed Apr 02 17:18:34 GMT 2025 , Edited by admin on Wed Apr 02 17:18:34 GMT 2025

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FDA UNII

W8VE86L4EU

Created by admin on Wed Apr 02 17:18:34 GMT 2025 , Edited by admin on Wed Apr 02 17:18:34 GMT 2025

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INN

12418

Created by admin on Wed Apr 02 17:18:34 GMT 2025 , Edited by admin on Wed Apr 02 17:18:34 GMT 2025

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Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					W8VE86L4EU

Inaticabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Inaticabtagene autoleucel lentiviral vector	W2K58PM7DQ
CULTURE	ACTIVATOR	BIOLOGICAL	ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Inaticabtagene autoleucel transgene insert	56UA23R9AU
VECTOR EXPRESSED PROTEIN					Inaticabtagene autoleucel expressed protein	RB9ANC2FMN