PANCOPRIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H24ClN3O2
Molecular Weight	349.855
Optical Activity	( + / - )
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=C(Cl)C=C(C(=O)N[C@@H]2C[N@@]3CC[C@H]2CC3)C(OCC4CC4)=C1

InChI

InChIKey=DBQMQBCSKXTCIJ-MRXNPFEDSA-N

InChI=1S/C18H24ClN3O2/c19-14-7-13(17(8-15(14)20)24-10-11-1-2-11)18(23)21-16-9-22-5-3-12(16)4-6-22/h7-8,11-12,16H,1-6,9-10,20H2,(H,21,23)/t16-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C18H24ClN3O2
Molecular Weight	349.855
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8804470 | https://www.ncbi.nlm.nih.gov/pubmed/1451737

Pancopride (LAS 30451) is a 5-hydroxytryptamine 3 receptor antagonist and was developed against cytotoxic drug-induced emesis. Pancopride was studied in clinical trials in patients treated with highly emetogenic chemotherapy. It was found a combination of Pancopride with dexamethasone was the most effective against chemotherapy-induced vomiting. However, information about the further development of this drug is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Single dose pharmacokinetics and tolerance of pancopride in healthy volunteers.	1995 Feb	7710444
Prevention of highly emetogenic chemotherapy-induced vomiting: a double blind, randomized crossover study to compare pancopride (LAS 30451) and pancopride plus dexamethasone.	1995 Nov-Dec	8804470

Sample Use Guides

In Vivo Use Guide

Pancopride (PNC) 0.2 mg/kg. i.v. 30 min before chemotherapy

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:29:37 GMT 2023` Edited by `admin` on `Fri Dec 15 16:29:37 GMT 2023`
Record UNII	W80HW6Q65O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PANCOPRIDE

Official Name

English

LAS-30451

Code

English

BENZAMIDE, 4-AMINO-N-1-AZABICYCLO(2.2.2)OCT-3-YL-5-CHLORO-2-(CYCLOPROPYLMETHOXY)-

Systematic Name

English

BENZAMIDE, 4-AMINO-N-1-AZABICYCLO(2.2.2)OCT-3-YL-5-CHLORO-2-(CYCLOPROPYLMETHOXY)-, (±)-

Systematic Name

English

LAS 30451

Code

English

(±)-4-AMINO-5-CHLORO-.ALPHA.-CYCLOPROPYL-N-3-QUINUCLIDINYL-O-ANISAMIDE

Common Name

English

pancopride [INN]

Common Name

English

PANCOPRIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885