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Details

Stereochemistry ACHIRAL
Molecular Formula C27H27FN8O3
Molecular Weight 530.5535
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GSK-1838705A

SMILES

CNC(=O)C1=C(F)C=CC=C1NC2=C3C=CNC3=NC(NC4=CC5=C(C=CN5C(=O)CN(C)C)C=C4OC)=N2

InChI

InChIKey=DESOLSKAHZZIGK-UHFFFAOYSA-N
InChI=1S/C27H27FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-13H,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34)

HIDE SMILES / InChI

Molecular Formula C27H27FN8O3
Molecular Weight 530.5535
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P08069
Gene ID: 3480.0
Gene Symbol: IGF1R
Target Organism: Homo sapiens (Human)
2.0 nM [IC50]
Target ID: P06213
Gene ID: 3643.0
Gene Symbol: INSR
Target Organism: Homo sapiens (Human)
1.6 nM [IC50]
PubMed

PubMed

TitleDatePubMed
GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.
2009 Oct
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:08:10 GMT 2023
Edited
by admin
on Sat Dec 16 10:08:10 GMT 2023
Record UNII
W6545R69M8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GSK-1838705A
Common Name English
BENZAMIDE, 2-((2-((1-(2-(DIMETHYLAMINO)ACETYL)-5-METHOXY-1H-INDOL-6-YL)AMINO)-7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)AMINO)-6-FLUORO-N-METHYL-
Systematic Name English
Code System Code Type Description
PUBCHEM
25113169
Created by admin on Sat Dec 16 10:08:10 GMT 2023 , Edited by admin on Sat Dec 16 10:08:10 GMT 2023
PRIMARY
CAS
1186659-59-5
Created by admin on Sat Dec 16 10:08:10 GMT 2023 , Edited by admin on Sat Dec 16 10:08:10 GMT 2023
PRIMARY
FDA UNII
W6545R69M8
Created by admin on Sat Dec 16 10:08:10 GMT 2023 , Edited by admin on Sat Dec 16 10:08:10 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY