REZATOMIDINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H16N2S
Molecular Weight	232.345
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H](C1=CNC(=S)N1)C2=CC=CC(C)=C2C

InChI

InChIKey=WQXVKEDUCPMRRI-JTQLQIEISA-N

InChI=1S/C13H16N2S/c1-8-5-4-6-11(9(8)2)10(3)12-7-14-13(16)15-12/h4-7,10H,1-3H3,(H2,14,15,16)/t10-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C13H16N2S
Molecular Weight	232.345
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.drugbank.ca/drugs/DB12143 | https://adisinsight.springer.com/drugs/800025948 | https://clinicaltrials.gov/ct2/show/NCT00445705 | https://clinicaltrials.gov/ct2/show/NCT00441766

Rezatomidine (AGN 203818) is an alpha adrenergic receptor agonist that was developed for the treatment of chronic pain conditions. Phase II studies have evaluated the safety and effectiveness of rezatomidine in treating the pain in patients with fibromyalgia, irritable bowel syndrome, interstitial cystitis, and diabetic neuropathy. However, three studies were terminated early based on a business decision. Pancreatitis, gastric ulcer, viral infections and dehydration were reported as serious adverse events in patients when administered a 60mg dose.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:25:33 GMT 2023` Edited by `admin` on `Fri Dec 15 17:25:33 GMT 2023`
Record UNII	W5LMZ0RC8I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

REZATOMIDINE

Official Name

English

REZATOMIDINE [USAN]

Common Name

English

Rezatomidine [WHO-DD]

Common Name

English

rezatomidine [INN]

Common Name

English

AGN-203818

Code

English

AGN203818

Code

English

2H-IMIDAZOLE-2-THIONE, 4-((1S)-1-(2,3-DIMETHYLPHENYL)ETHYL)-1,3-DIHYDRO-

Systematic Name

English

AGN-203818 FREE BASE

Code

English

2H-IMIDAZOLE-2-THIONE, 4-(1-(2,3-DIMETHYLPHENYL)ETHYL)-1,3-DIHYDRO-

Systematic Name

English

(+)-4-((1S)-1-(2,3-DIMETHYLPHENYL)ETHYL)-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE

Systematic Name

English

4-(1-(2,3-DIMETHYLPHENYL)ETHYL)-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE

Systematic Name

English

4-((1S)-1-(2,3-DIMETHYLPHENYL)ETHYL)-1,3-DIHYDRO-2H-IMIDAZOL-2-THIONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29713