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Details

Stereochemistry ACHIRAL
Molecular Formula C13H14N4O2
Molecular Weight 258.2759
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PRINOXODAN

SMILES

CN1CC2=CC(=CC=C2NC1=O)C3=NNC(=O)CC3

InChI

InChIKey=SUCNEHPNQBBVHQ-UHFFFAOYSA-N
InChI=1S/C13H14N4O2/c1-17-7-9-6-8(2-3-10(9)14-13(17)19)11-4-5-12(18)16-15-11/h2-3,6H,4-5,7H2,1H3,(H,14,19)(H,16,18)

HIDE SMILES / InChI

Molecular Formula C13H14N4O2
Molecular Weight 258.2759
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Prinoxodan (also known as RGW2938) is a benzodiazinone derivative patented by Rorer International (Overseas), Inc as inotropic agents, useful in treating congestive heart failure. Prinoxodan administered intravenously (i.v.) to anesthetized dogs increased contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. A single oral dose of Prinoxodan administered to conscious chronically instrumented dogs produced a marked and sustained increase in contractility 15-240 min after treatment.

Approval Year

PubMed

PubMed

TitleDatePubMed
Determination of a new inotropic agent in human plasma by high-performance liquid chromatography.
1988 Dec 28
Patents

Patents

Sample Use Guides

Dog 0.3 mg/kg
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:59:01 GMT 2023
Edited
by admin
on Sat Dec 16 17:59:01 GMT 2023
Record UNII
W4VMH2E80M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PRINOXODAN
INN   USAN  
INN   USAN  
Official Name English
PRINOXODAN [USAN]
Common Name English
3,4-Dihydro-3-methyl-6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2(1H)-quinazolinone
Systematic Name English
RGW-2938
Code English
prinoxodan [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C744
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
Code System Code Type Description
USAN
BB-71
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
MESH
C059401
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
EVMPD
SUB10048MIG
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
SMS_ID
100000081108
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
CAS
111786-07-3
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
INN
6657
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
FDA UNII
W4VMH2E80M
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
EPA CompTox
DTXSID10149732
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105205
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
PUBCHEM
5362397
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
NCI_THESAURUS
C74349
Created by admin on Sat Dec 16 17:59:01 GMT 2023 , Edited by admin on Sat Dec 16 17:59:01 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY