CLOBUZARIT

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H17ClO3
Molecular Weight	304.768
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(OCC1=CC=C(C=C1)C2=CC=C(Cl)C=C2)C(O)=O

InChI

InChIKey=UGOFYAXVVVXMQT-UHFFFAOYSA-N

InChI=1S/C17H17ClO3/c1-17(2,16(19)20)21-11-12-3-5-13(6-4-12)14-7-9-15(18)10-8-14/h3-10H,11H2,1-2H3,(H,19,20)

HIDE SMILES / InChI

Molecular Formula	C17H17ClO3
Molecular Weight	304.768
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.sciencedirect.com/science/article/pii/S0065774308611306

Clobuzarit (Clozic) is a compound originally developed for the treatment of atherosclerosis. It was later found to possess antirheumatic and weak anti-inflammatory properties and was evaluated as a disease-modifying antirheumatic drug. Adverse side effects observed in clinical trials have forced the withdrawal of clobuzarit from further consideration.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:17:38 GMT 2025` Edited by `admin` on `Mon Mar 31 18:17:38 GMT 2025`
Record UNII	W3D7B06505
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ICI 55,897

Preferred Name

English

CLOBUZARIT

Official Name

English

ICI-55897

Code

English

clobuzarit [INN]

Common Name

English

CLOBUZARIT [MI]

Common Name

English

2-((4'-CHLORO-4-BIPHENYLYL)METHOXY)-2-METHYLPROPIONIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257