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Details

Stereochemistry ACHIRAL
Molecular Formula C17H15NO5
Molecular Weight 313.3047
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENORILATE

SMILES

CC(=O)NC1=CC=C(OC(=O)C2=C(OC(C)=O)C=CC=C2)C=C1

InChI

InChIKey=FEJKLNWAOXSSNR-UHFFFAOYSA-N
InChI=1S/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19)

HIDE SMILES / InChI
Molecular Formula C17H15NO5
Molecular Weight 313.3047
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: www.drugfuture.com/mt/bendazac.pdf http://pmmp.cnki.net/Resources/CDDPdf/med%5Cbase%5C%E7%A5%9E%E7%BB%8F%E7%B3%BB%E7%BB%9F%E8%8D%AF%E7%89%A9%5C259.pdf http://ru.medicina-617.medicina.eh.org.ua/42.htm https://en.wikipedia.org/wiki/Benorilate

Benorilate is an aspirin-paracetamol ester with analgesic, antiinflammatory, and antipyretic properties. After absorption, it is rapidly metabolised to salicylate and paracetamol. It has been used orally in the treatment of mild to moderate pain and fever. It has also been used in osteoarthritis, rheumatoid arthritis, and soft-tissue rheumatism. Associated adverse reactions: nausea, diarrhea or constipation, digestive disorders or heartburn, occasionally - a transient skin rash, and sleepiness. Benoral should not be administered concomitantly with probenecid or any other uricosuric agents that decrease tubular reabsorption as any form of salicylate antagonises this effect when given in doses of less than 5 gm per day.

CNS Activity

CNS Non-penetrant
1014
Curator's Comment: Benorilate is unable to cross the Blood-brain barrier by themselves but finally enter the brain after a metabolic modification.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
prostaglandin biosynthetic process
23
Target ID: GO:0001516
Sources: Rheumatology (1973) XII (suppl): 101-105 doi:10.1093/rheumatology/XII.suppl.101
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Withdrawn
Unknown

Approved Use

Benorylate is indicated in the treatment of rheumatoid arthritis.
Palliative
Withdrawn
Unknown

Approved Use

Benorylate is indicated in the treatment of osteoarthritis.
Palliative
Withdrawn
Unknown

Approved Use

Benorylate is indicated in the treatment of painful musculoskeletal conditions.
PubMed

PubMed

TitleDatePubMed
Comparison of aspirin and benorylate in the treatment of rheumatoid arthritis.
1972 May 27
Calorimetric relaxation in pharmaceutical molecular glasses and its utility in understanding their stability against crystallization.
2008 Sep 4
Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles.
2009
Patents

Patents

US3431293 A
1

Sample Use Guides

In Vivo Use Guide
Curator's Comment: 1,5 g (2 tablets) 4 times per day. In acute phase - 6 g per day http://ru.medicina-617.medicina.eh.org.ua/42.htm
The dose​ of benorylate is 6-8 g daily.
Route of Administration: Oral
In Vitro Use Guide
Because of the very rapid hydrolysis of benorylate by liver samples, hydrolysis conditions of 300 uM benorylate plus microsomes (4ug protein equivalent to 0,8 mg liver per incubation) were selected such that benorylate was detectable for 30 min and only 50% disappeared over the first 15 min.
Substance Class Chemical
Created
by admin
on Fri Dec 15 14:58:22 UTC 2023
Edited
by admin
on Fri Dec 15 14:58:22 UTC 2023
Record UNII
W1QX9DV96G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BENORILATE
INN   MART.   WHO-DD  
INN  
Official Name English
WIN 11450
Code English
Benorilate [WHO-DD]
Common Name English
4-ACETAMIDOPHENYL SALICYLATE ACETATE
Systematic Name English
BENORYLATE
MI  
Common Name English
benorilate [INN]
Common Name English
BENORILATE [MART.]
Common Name English
BENORYLATE [MI]
Common Name English
WIN-11450
Code English
FENASPRATE
Common Name English
Classification Tree Code System Code
WHO-VATC QN02BA10
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
NCI_THESAURUS C257
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
WHO-ATC N02BA10
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
Code System Code Type Description
SMS_ID
100000091939
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
FDA UNII
W1QX9DV96G
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
MERCK INDEX
m2317
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C80538
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
EPA CompTox
DTXSID5022649
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
MESH
C084830
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
ECHA (EC/EINECS)
225-674-5
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
PUBCHEM
21102
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
DRUG CENTRAL
310
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
WIKIPEDIA
BENORILATE
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
EVMPD
SUB05722MIG
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
CAS
5003-48-5
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
INN
2297
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
ChEMBL
CHEMBL162036
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
RXCUI
1372
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY RxNorm
DRUG BANK
DB13657
Created by admin on Fri Dec 15 14:58:22 UTC 2023 , Edited by admin on Fri Dec 15 14:58:22 UTC 2023
PRIMARY
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Related Record Type Details
Structure of BENORILATE
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