BMS-641988

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H20F3N3O5S
Molecular Weight	471.45
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12C(=O)N(C(=O)[C@@]1([H])[C@@]3(C)O[C@]2(C)C[C@H]3NS(=O)(=O)CC)C4=CC=C(C#N)C(=C4)C(F)(F)F

InChI

InChIKey=HYNANJUKEMCYEQ-HIGHGGLBSA-N

InChI=1S/C20H20F3N3O5S/c1-4-32(29,30)25-13-8-18(2)14-15(19(13,3)31-18)17(28)26(16(14)27)11-6-5-10(9-24)12(7-11)20(21,22)23/h5-7,13-15,25H,4,8H2,1-3H3/t13-,14-,15+,18-,19+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H20F3N3O5S
Molecular Weight	471.45
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19654297 | https://www.ncbi.nlm.nih.gov/pubmed/26288692

Bristol-Myers Squibb developed BMS-641988 as a nonsteroidal androgen receptor antagonist for the treatment of prostate cancer. BMS-641988 participated in phase I clinical trials in patients with castration-resistant prostate cancer in Japan and in the USA. However, further information is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer.	2009 Aug 15	19654297
Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists.	2011 Nov 10	21936524
Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.	2011 Sep 22	21846139
Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.	2015 Aug 13	26288692

Sample Use Guides

In Vivo Use Guide

Drug: BMS-641988 (AR#2) Tablets, Oral, 20 mg, 40 mg, 60 mg, 100 mg, once daily, 24 weeks

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:40:31 GMT 2023` Edited by `admin` on `Sat Dec 16 04:40:31 GMT 2023`
Record UNII	W17M53Y8IM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BMS-641988

Common Name

English

BMS 641988 [WHO-DD]

Common Name

English

ETHANESULFONAMIDE, N-((3AR,4R,5R,7R,7AS)-2-(4-CYANO-3-(TRIFLUOROMETHYL)PHENYL)OCTAHYDRO-4,7-DIMETHYL-1,3-DIOXO-4,7-EPOXY-1H-ISOINDOL-5-YL)-

Systematic Name

English

Code System Code Type Description

FDA UNII

W17M53Y8IM