BUTHIAZIDE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H16ClN3O4S2
Molecular Weight	353.845
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CC1NC2=CC(Cl)=C(C=C2S(=O)(=O)N1)S(N)(=O)=O

InChI

InChIKey=HGBFRHCDYZJRAO-UHFFFAOYSA-N

InChI=1S/C11H16ClN3O4S2/c1-6(2)3-11-14-8-4-7(12)9(20(13,16)17)5-10(8)21(18,19)15-11/h4-6,11,14-15H,3H2,1-2H3,(H2,13,16,17)

HIDE SMILES / InChI

Molecular Formula	C11H16ClN3O4S2
Molecular Weight	353.845
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.genome.jp/dbget-bin/www_bget?dr:D03189 | https://www.ncbi.nlm.nih.gov/pubmed/1505173 | https://www.ncbi.nlm.nih.gov/pubmed/7285534 | http://www.reference.md/files/C016/mC016210.html

Buthiazide (or Butizide) is a diuretic of the thiazide class. It was used for the treatment of mild to moderate essential hypertension. Buthiazide reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Thiazide-sensitive sodium-chloride cotransporter 28 Target ID: CHEMBL1876 Sources: https://patents.google.com/patent/WO2014076235A1 \| https://www.ncbi.nlm.nih.gov/pubmed/7967362	Inhibitor 8504

PubMed

Title	Date	PubMed
[Chlorthalidone better than hydrochlorothiazide in hypertension].	2010	20456766
Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases.	2009-09	19567519
Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure.	2009-08	19531963
Amlodipine/valsartan/hydrochlorothiazide: fixed-dose combination in hypertension.	2009	19929039
LC and LC-MS methods for the investigation of polypills for the treatment of cardiovascular diseases. Part 1. Separation of active components and classification of their interaction/degradation products.	2008-07-15	18343073
Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.	2005-08	16044110
A case of gain-of-function mutation in calcium-sensing receptor: supplemental hydration is required for renal protection.	2005-06	15960151
[Anxiodepressive and neuromediatory disorders in hypertensive patients. Effects of cypramil therapy].	2005	16404864
Phototoxicity to diuretics and antidiabetics in the cultured keratinocyte cell line HaCaT: evaluation by clonogenic assay and single cell gel electrophoresis Comet assay).	2002-04	12147042
Ex vivo antigen preparation for the serological detection of drug-dependent antibodies in immune haemolytic anaemias.	1984-11	6208933

Sample Use Guides

In Vivo Use Guide

The combination of 100 mg spironolactone either with 5 mg bendrofluazide or with 10 mg butizide increased significantly the diuresis over the whole day.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:32:33 GMT 2025` Edited by `admin` on `Mon Mar 31 19:32:33 GMT 2025`
Record UNII	W00SSD35VW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUTHIAZIDE

Official Name

English

BUTIZIDE

Preferred Name

English

6-Chloro-3,4-dihydro-3-isobutyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Systematic Name

English

BUTHIAZIDE [MI]

Common Name

English

BUTIZIDE [MART.]

Common Name

English

butizide [INN]

Common Name

English

BUTHIAZIDE [USAN]

Common Name

English

ISOBUTYLHYDROCHLOROTHIAZIDE

Common Name

English

Butizide [WHO-DD]

Common Name

English

2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-3,4-DIHYDRO-3-(2-METHYLPROPYL)-, 1,1-DIOXIDE

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QC03EA14