FAZULEMERAN

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 12:56:32 GMT 2025` Edited by `admin` on `Wed Apr 02 12:56:32 GMT 2025`
Nucleic Acid Type	MRNA
Sequence Type	COMPLETE
Record UNII	VX5UYL72J2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FAZULEMERAN

Official Name

English

MESSENGER RNA (MRNA), 5' CAPPED, ENCODING HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR A (VASCULAR PERMEABILITY FACTOR (VPF)), ISOFORM 165 (VEGF165, VEGF-A165), FURTHER OPTIMIZED BY TWO ADDITIONAL STOP CODONS, FLANKED BY AN ARTIFICIAL 5' UNTRANSLATED REGION

Preferred Name

English

fazulemeran [INN]

Common Name

English

RNA (RECOMBINANT 5'-(M7G-(5'->5')-PPP-AM)-CAPPED ALL URIDINE->N1-METHYLPSEUDOURIDINE-SUBSTITUTED HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR A-SPECIFYING POLY(A)-TAILED MESSENGER CX-018124), INNER SALT

Common Name

English

Code System Code Type Description

SMS_ID

300000051826

Created by admin on Wed Apr 02 12:56:32 GMT 2025 , Edited by admin on Wed Apr 02 12:56:32 GMT 2025

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FDA UNII

VX5UYL72J2

Created by admin on Wed Apr 02 12:56:32 GMT 2025 , Edited by admin on Wed Apr 02 12:56:32 GMT 2025

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CAS

2417174-26-4

Created by admin on Wed Apr 02 12:56:32 GMT 2025 , Edited by admin on Wed Apr 02 12:56:32 GMT 2025

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NCI_THESAURUS

C184900

Created by admin on Wed Apr 02 12:56:32 GMT 2025 , Edited by admin on Wed Apr 02 12:56:32 GMT 2025

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INN

11763

Created by admin on Wed Apr 02 12:56:32 GMT 2025 , Edited by admin on Wed Apr 02 12:56:32 GMT 2025

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Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_844	844 / 844

Linkage	Site Range	Site Count
Phosphate	1_2-1_844	843 / 843

Related Record Type Details


					NZN256ZSV8

HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR A

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					VX5UYL72J2

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		N1-METHYLPSEUDOURIDINE	09RAD4M6WF
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			7M-G-PPP-2'M-A-P MRNA CAP	P7W5ZN6FY2