Stereochemistry | EPIMERIC |
Molecular Formula | C20H20N6O9S |
Molecular Weight | 520.473 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CO[C@]2(NC(=O)C(C(O)=O)C1=CC=C(O)C=C1)[C@H]3OCC(CSC4=NN=NN4C)=C(N3C2=O)C(O)=O
InChI
InChIKey=JWCSIUVGFCSJCK-CAVRMKNVSA-N
InChI=1S/C20H20N6O9S/c1-25-19(22-23-24-25)36-8-10-7-35-18-20(34-2,17(33)26(18)13(10)16(31)32)21-14(28)12(15(29)30)9-3-5-11(27)6-4-9/h3-6,12,18,27H,7-8H2,1-2H3,(H,21,28)(H,29,30)(H,31,32)/t12?,18-,20+/m1/s1
Molecular Formula | C20H20N6O9S |
Molecular Weight | 520.473 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | EPIMERIC |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 3 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Moxalactam (latamoxef) is a new synthetic oxa-beta-lactam antibiotic administered intravenously or intramuscularly. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, is particularly active against Enterobacteriaceae and is resistant to hydrolysis by beta-lactamases. Moxalactam has moderate activity against Pseudomonas aeruginosa, but on the basis of present evidence can not be recommended as sole antibiotic treatment of known or suspected pseudomonal infections. Like the related compounds, the cephalosporins, moxalactam is effective in the treatment of complicated urinary tract infections and lower respiratory tract infections caused by Gram-negative bacilli. Latamoxef works by inhibiting bacterial cell wall biosynthesis. Latamoxef is primarily indicated in conditions like Bone and joint infection, GI infections, Gynecological infections, Meningitis, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, UTI. Latamoxef is no longer available in the United States.
CNS Activity
Originator
Approval Year
Doses
AEs
Sourcing
PubMed
Patents
Sample Use Guides
Intramuscular
Susceptible infections
Adult: 2 g/day in 2 divided doses.
Child: 50-100 mg/kg/day in 2-3 divided doses.
Intravenous
Susceptible infections
Adult: 2-6 g/day in 2-3 divided doses.
Child: 50-100 mg/kg/day in 2-3 divided doses.
Intravenous
Meningitis
Child: 100 mg/kg as loading dose.
Route of Administration:
Parenteral