Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H28FN3O |
Molecular Weight | 357.4649 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NC(OCCCCCN2CCCCC2)=CC(=N1)C3=CC=C(F)C=C3
InChI
InChIKey=SZSHJTJCJOWMHM-UHFFFAOYSA-N
InChI=1S/C21H28FN3O/c1-17-23-20(18-8-10-19(22)11-9-18)16-21(24-17)26-15-7-3-6-14-25-12-4-2-5-13-25/h8-11,16H,2-7,12-15H2,1H3
Molecular Formula | C21H28FN3O |
Molecular Weight | 357.4649 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Enecadin (NS 7 or ZK 228326) is a voltage-dependent sodium and calcium channel blocker. Enecadin is a neuroprotective agent demonstrated efficacy in animal models of ischemic injury of brain, spinal cord and retina. Enecadin was undergoing phase II development in stroke with PAION in Germany. Enecadin development has been discontinued.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2362985 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18377333 |
|||
Target ID: CHEMBL2363032 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18377333 |
PubMed
Title | Date | PubMed |
---|---|---|
Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7. I. Effect on the cerebral infarction and edema at the acute stage of permanent middle cerebral artery occlusion in rats. | 2001 Jan 26 |
|
A novel voltage-sensitive Na(+) and Ca(2+) channel blocker, NS-7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat. | 2002 Jan 4 |
|
Pharmacokinetics of the new pyrimidine derivative NS-7, a novel Na+/Ca2+ channel blocker. 1st communication: plasma concentrations and excretions after a single intravenous 14C-NS-7 injection to rats, dogs and monkeys. | 2003 |
|
Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes. | 2005 Jun |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11589782
In rat dorsal root ganglion neurones, NS-7 (0.3-100 microM) inhibited the whole-cell Ba(2+) currents (IBa) in a voltage-dependent manner, in which the compound more potently blocked the IBa elicited from the holding potential of -40 mV than that induced from -80 mV.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:01:10 GMT 2023
by
admin
on
Fri Dec 15 16:01:10 GMT 2023
|
Record UNII |
VR034VW8OG
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C1509
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
VR034VW8OG
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
PRIMARY | |||
|
8275
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
PRIMARY | |||
|
DTXSID30948865
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
PRIMARY | |||
|
C83807
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
PRIMARY | |||
|
DB13032
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
PRIMARY | |||
|
100000178252
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
PRIMARY | |||
|
259525-01-4
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
PRIMARY | |||
|
6433114
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
PRIMARY | |||
|
CHEMBL29404
Created by
admin on Fri Dec 15 16:01:10 GMT 2023 , Edited by admin on Fri Dec 15 16:01:10 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |