GLIBORNURIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H26N2O4S
Molecular Weight	366.475
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(C=C1)S(=O)(=O)NC(=O)N[C@@H]2[C@H](O)[C@]3(C)CC[C@H]2C3(C)C

InChI

InChIKey=RMTYNAPTNBJHQI-LLDVTBCESA-N

InChI=1S/C18H26N2O4S/c1-11-5-7-12(8-6-11)25(23,24)20-16(22)19-14-13-9-10-18(4,15(14)21)17(13,2)3/h5-8,13-15,21H,9-10H2,1-4H3,(H2,19,20,22)/t13-,14+,15+,18+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C18H26N2O4S
Molecular Weight	366.475
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://medikamio.com/de-ch/medikamente/glutril/pil

Glibornuride is sulphonylurea derivative used as an oral hypoglycemic drug in patients with diabetes. The drug was marketed under the name Glutril, however, it is no longer available.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetes mellitus 93 Sources: https://www.ncbi.nlm.nih.gov/pubmed/126099	Primary		Approved 8583	GLUTRIL Approved Use Glutril is used for the treatment of diabetes.

AUC

Value	Dose	Co-administered	Analyte	Population
18.5 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3157397/	25 mg single, intravenous dose: 25 mg route of administration: Intravenous experiment type: SINGLE co-administered:		GLIBORNURIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
9.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3157397/	25 mg single, intravenous dose: 25 mg route of administration: Intravenous experiment type: SINGLE co-administered:		GLIBORNURIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Doses

Dose	Population	Adverse events
50 mg 1 times / day multiple, oral Studied dose Dose: 50 mg, 1 times / day Route: oral Route: multiple Dose: 50 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/153973/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/153973/	Sources: https://pubmed.ncbi.nlm.nih.gov/153973/

PubMed

Title	Date	PubMed
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.	2008-11	18782901
Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats.	2006-03-08	16223573
Effects of glibornuride versus metformin on eye lenses and skin in experimental diabetes.	2006	16927537
Identification and quantification of 8 sulfonylureas with clinical toxicology interest by liquid chromatography-ion-trap tandem mass spectrometry and library searching.	2005-09	16020498
The morphological and biochemical effects of glibornuride on rat liver in experimental diabetes.	2004-05	15228018
Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry.	2002-06-15	12015271

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose is 0.5 tablet (1 tablet contains 25 mg of glibornuride) per day, given at breakfast time. Do not take more than 3 tablets per day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:53:02 GMT 2025` Edited by `admin` on `Mon Mar 31 17:53:02 GMT 2025`
Record UNII	VP83E7434R
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GLIBORNURIDE

Official Name

English

GLUTRIL

Preferred Name

English

GLIBORNURIDE [MART.]

Common Name

English

RO 6-4563

Code

English

GLIBORNURIDE [USAN]

Common Name

English

RO-6-4563

Code

English

BENZENESULFONAMIDE, N-(((3-HYDROXY-4,7,7-TRIMETHYLBICYCLO(2.2.1)HEPT-2-YL)AMINO)CARBONYL)-4-METHYL-, (1S-(ENDO, ENDO))-

Common Name

English

Glibornuride [WHO-DD]

Common Name

English

ENDO, ENDO-1-((1R)-(2-HYDROXY-3-BORNYL))-3-(P-TOLYLSULFONYL)UREA

Common Name

English

glibornuride [INN]

Common Name

English

GLIBORNURIDE [MI]

Common Name

English

RO-64563

Code

English

Classification Tree Code System Code

WHO-VATC

QA10BB04