Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H27FN2O.ClH |
| Molecular Weight | 390.922 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCC(=O)N(C1CCN(CCC2=CC=CC=C2)CC1)C3=CC=C(F)C=C3
InChI
InChIKey=CTXOPDVNXMUJCV-UHFFFAOYSA-N
InChI=1S/C22H27FN2O.ClH/c1-2-22(26)25(20-10-8-19(23)9-11-20)21-13-16-24(17-14-21)15-12-18-6-4-3-5-7-18;/h3-11,21H,2,12-17H2,1H3;1H
| Molecular Formula | C22H27FN2O |
| Molecular Weight | 354.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Originator
Approval Year
Sample Use Guides
On a black market, parafluorofentanyl is distributed in form of capsules and tablets containing the drug in the range of 33.8-408.7 ug. In preclinical studies parafluorofentanyl was administered to rats subcutaneously.
Route of Administration:
Other
The potency of parafluorofentanyl with respect to cloned hMOR was investigated using the heterologous expression in X. laevis. Receptor subtype was individually coexpressed with GIRK1/GIRK2 channels and RGS4, mimicking the native neuronal G protein-mediated pathway of K1 channel activation. The two-microelectrode voltage-clamp technique was then used to measure the opioid receptor-activated GIRK1/GIRK2 channel response as the increase of the inward K1 current at 270 mV, evoked by the application of increasing concentrations of opioid ligands. Parafluorofentanyl activated hMOR with EC50 of 4.2 nM.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:28:07 UTC 2023
by
admin
on
Sat Dec 16 11:28:07 UTC 2023
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| Record UNII |
VP0NU00C3G
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| Record Status |
Validated (UNII)
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| Record Version |
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VP0NU00C3G
Created by
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DTXSID101036756
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117332-92-0
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admin on Sat Dec 16 11:28:07 UTC 2023 , Edited by admin on Sat Dec 16 11:28:07 UTC 2023
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138455085
Created by
admin on Sat Dec 16 11:28:07 UTC 2023 , Edited by admin on Sat Dec 16 11:28:07 UTC 2023
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
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