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Details

Stereochemistry ACHIRAL
Molecular Formula C22H27FN2O.ClH
Molecular Weight 390.922
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of P-FLUOROFENTANYL HYDROCHLORIDE

SMILES

Cl.CCC(=O)N(C1CCN(CCC2=CC=CC=C2)CC1)C3=CC=C(F)C=C3

InChI

InChIKey=CTXOPDVNXMUJCV-UHFFFAOYSA-N
InChI=1S/C22H27FN2O.ClH/c1-2-22(26)25(20-10-8-19(23)9-11-20)21-13-16-24(17-14-21)15-12-18-6-4-3-5-7-18;/h3-11,21H,2,12-17H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula C22H27FN2O
Molecular Weight 354.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Parafluorofentanyl is a selective mu-opioid agonist, an analog of fentanyl, developed by Janssen. The drug was not developed for human use but is produced and abused illegally.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
4.2 nM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

On a black market, parafluorofentanyl is distributed in form of capsules and tablets containing the drug in the range of 33.8-408.7 ug. In preclinical studies parafluorofentanyl was administered to rats subcutaneously.
Route of Administration: Other
The potency of parafluorofentanyl with respect to cloned hMOR was investigated using the heterologous expression in X. laevis. Receptor subtype was individually coexpressed with GIRK1/GIRK2 channels and RGS4, mimicking the native neuronal G protein-mediated pathway of K1 channel activation. The two-microelectrode voltage-clamp technique was then used to measure the opioid receptor-activated GIRK1/GIRK2 channel response as the increase of the inward K1 current at 270 mV, evoked by the application of increasing concentrations of opioid ligands. Parafluorofentanyl activated hMOR with EC50 of 4.2 nM.
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:28:07 GMT 2023
Edited
by admin
on Sat Dec 16 11:28:07 GMT 2023
Record UNII
VP0NU00C3G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
P-FLUOROFENTANYL HYDROCHLORIDE
Common Name English
PROPANAMIDE, N-(4-FLUOROPHENYL)-N-(1-(2-PHENYLETHYL)-4-PIPERIDINYL)-, MONOHYDROCHLORIDE
Common Name English
PROPANAMIDE, N-(4-FLUOROPHENYL)-N-(1-(2-PHENYLETHYL)-4-PIPERIDINYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
PARA-FLUOROFENTANYL HYDROCHLORIDE
Common Name English
PARA-FLUOROFENTANYL HYDROCHLORIDE SALT
Common Name English
NIH-10491
Code English
Code System Code Type Description
FDA UNII
VP0NU00C3G
Created by admin on Sat Dec 16 11:28:07 GMT 2023 , Edited by admin on Sat Dec 16 11:28:07 GMT 2023
PRIMARY
EPA CompTox
DTXSID101036756
Created by admin on Sat Dec 16 11:28:07 GMT 2023 , Edited by admin on Sat Dec 16 11:28:07 GMT 2023
PRIMARY
CAS
117332-92-0
Created by admin on Sat Dec 16 11:28:07 GMT 2023 , Edited by admin on Sat Dec 16 11:28:07 GMT 2023
PRIMARY
PUBCHEM
138455085
Created by admin on Sat Dec 16 11:28:07 GMT 2023 , Edited by admin on Sat Dec 16 11:28:07 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)