HI-TOPK-032

O=C(NC1=CC2=C(C#N)C3=NC4=CC=CC=C4N=C3N2C=C1)C5=CC=CS5

InChIKey=BCSBXWKRZUPFHW-UHFFFAOYSA-N

InChI=1S/C20H11N5OS/c21-11-13-16-10-12(22-20(26)17-6-3-9-27-17)7-8-25(16)19-18(13)23-14-4-1-2-5-15(14)24-19/h1-10H,(H,22,26)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Serine/threonine-protein kinase Chk1 23 Target ID: O14757 Gene ID: 1111.0 Gene Symbol: CHEK1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21955044	Inhibitor 8504	9.6 µM [IC50]
Lymphokine-activated killer T-cell-originated protein kinase 1 Target ID: Q96KB5 Gene ID: 55872.0 Gene Symbol: PBK Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/22523035	Inhibitor 8504
Dual specificity mitogen-activated protein kinase kinase 1 20 Target ID: Q02750 Gene ID: 5604.0 Gene Symbol: MAP2K1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/22523035	Inhibitor 8504

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:33:02 GMT 2025` Edited by `admin` on `Mon Mar 31 23:33:02 GMT 2025`
Record UNII	VH977A8H53
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

N-(12-CYANOINDOLIZINO(2,3-B)QUINOXALIN-2-YL)-2-THIOPHENECARBOXAMIDE

Preferred Name

English

HI-TOPK-032

Common Name

English

2-THIOPHENECARBOXAMIDE, N-(12-CYANOINDOLIZINO(2,3-B)QUINOXALIN-2-YL)-

Systematic Name

English

Code System Code Type Description

FDA UNII

VH977A8H53

Created by admin on Mon Mar 31 23:33:02 GMT 2025 , Edited by admin on Mon Mar 31 23:33:02 GMT 2025

PRIMARY

PUBCHEM

1936439

Created by admin on Mon Mar 31 23:33:02 GMT 2025 , Edited by admin on Mon Mar 31 23:33:02 GMT 2025

PRIMARY

CAS

487020-03-1

Created by admin on Mon Mar 31 23:33:02 GMT 2025 , Edited by admin on Mon Mar 31 23:33:02 GMT 2025

PRIMARY

Related Record Type Details


					VH977A8H53

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