L-377202

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C65H89N9O25
Molecular Weight	1396.4475
Optical Activity	UNSPECIFIED
Defined Stereocenters	14 / 14
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=CC2=C1C(=O)C3=C(O)C4=C(C[C@](O)(C[C@@H]4O[C@H]5C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]6C[C@@H](O)CN6C(=O)CCCC(O)=O)C7CCCCC7)[C@H](O)[C@H](C)O5)C(=O)CO)C(O)=C3C2=O

InChI

InChIKey=CZXGBIFEWYVYJY-NPLULESDSA-N

InChI=1S/C65H89N9O25/c1-28(2)19-37(60(91)69-36-21-47(98-30(4)53(36)84)99-42-23-65(96,43(79)27-77)22-34-49(42)57(88)51-50(55(34)86)54(85)33-13-9-14-41(97-5)48(33)56(51)87)70-61(92)38(25-75)72-59(90)35(17-18-44(66)80)68-64(95)52(31-11-7-6-8-12-31)73-62(93)39(26-76)71-58(89)29(3)67-63(94)40-20-32(78)24-74(40)45(81)15-10-16-46(82)83/h9,13-14,28-32,35-40,42,47,52-53,75-78,84,86,88,96H,6-8,10-12,15-27H2,1-5H3,(H2,66,80)(H,67,94)(H,68,95)(H,69,91)(H,70,92)(H,71,89)(H,72,90)(H,73,93)(H,82,83)/t29-,30-,32+,35-,36-,37-,38-,39-,40-,42-,47-,52-,53+,65-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C65H89N9O25
Molecular Weight	1396.4475
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	14 / 14
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:45:04 GMT 2023` Edited by `admin` on `Fri Dec 15 15:45:04 GMT 2023`
Record UNII	VDXVABRQTV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

L-377202

Code

English

5-((2S,4R)-2-(((1S)-2-(((1S)-2-(((1S)-2-(((1S)-4-AMINO-1-(((1S)-1-(HYDROXYMETHYL)-2-(((1S)-1-(((2S,3S,4S,6R)-3-HYDROXY-2-METHYL-6-(((1S,3S)-3,5,12-TRIHYDROXY-3-(2-HYDROXYACETYL)-10-METHOXY-6,11-DIOXO-2,4-DIHYDRO-1H-TETRACEN-1-YL)OXY)TETRAHYDROPYRAN-4-YL)

Systematic Name

English

L-377202-000H

Code

English

5,12-NAPHTHACENEDIONE, 10-((3-(((4R)-1-(4-CARBOXY-1-OXOBUTYL)-4-HYDROXY-L-PROLYL-L-ALANYL-L-SERYL-(2S)-2-CYCLOHEXYLGLYCYL-L-GLUTAMINYL-L-SERYL-L-LEUCYL)AMINO)-2,3,6-TRIDEOXY-.ALPHA.-L-LYXO-HEXOPYRANOSYL)OXY)-7,8,9,10-TETRAHYDRO-6,8,11-TRIHYDROXY-8-(2-HYD

Systematic Name

English

Code System Code Type Description

PUBCHEM

9855284

Created by admin on Fri Dec 15 15:45:04 GMT 2023 , Edited by admin on Fri Dec 15 15:45:04 GMT 2023

PRIMARY

CAS

207395-85-5

Created by admin on Fri Dec 15 15:45:04 GMT 2023 , Edited by admin on Fri Dec 15 15:45:04 GMT 2023

PRIMARY

NCI_THESAURUS

C1853

Created by admin on Fri Dec 15 15:45:04 GMT 2023 , Edited by admin on Fri Dec 15 15:45:04 GMT 2023

PRIMARY

FDA UNII

VDXVABRQTV

Created by admin on Fri Dec 15 15:45:04 GMT 2023 , Edited by admin on Fri Dec 15 15:45:04 GMT 2023

PRIMARY

Related Record Type Details


					VDXVABRQTV

L-377202

ACTIVE MOIETY

Comments:

L-377,202 was approximately 15 times more effective than was conventional doxorubicin at inhibiting the growth of human prostate cancer tumors in nude mice when both drugs were used at their maximally tolerated doses.


					VDXVABRQTV

L-377202

ACTIVE MOIETY

Comments:

For each cycle, L-377202 will be administered as a 30-minute infusion every 3 weeks. The starting dose will be 20 mg/m2/week. Doses will be doubled until a patient experiences a greater than or equal to Grade 2 toxicity.


					VDXVABRQTV

L-377202

ACTIVE MOIETY

Comments:

A prodrug in which a peptide is covalently conjugated with the anthracycline antineoplastic antibiotic doxorubicin.