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Details

Stereochemistry ACHIRAL
Molecular Formula Co.O
Molecular Weight 74.9326
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALTOUS OXIDE

SMILES

[O--].[Co++]

InChI

InChIKey=IUYLTEAJCNAMJK-UHFFFAOYSA-N
InChI=1S/Co.O/q+2;-2

HIDE SMILES / InChI

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Co
Molecular Weight 58.933195
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Cobalt is a transition metal, naturally ocurring in the minerals cobaltite, smaltite, and erythrite, and is often associated with nickel, silver, lead, copper, and iron ores, from which it is most frequently obtained as a by-product. Depending on the considered species, cobalt has multiple industrial applications including the production of alloys and hard metal, diamond polishing, drying agents, pigments and catalysts. Cobalt is an essential component of Vitamin B12 (hydroxycolalamin). Cobalt functions as a co-factor in enzyme catalysed reactions and is involved in the production of erythropoietin, a hormone that stimulates the formation of erythrocytes. Cobalt salts were used to treat anemia and stimulate erythropoiesis, but was withdrawn from market since Co(II) cations are genotoxic in vitro and in vivo, and carcinogenic in rodents. Hovewer, Co salts are reported to be used by athletes as a doping

Originator

Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
1.0 µM [Ki]
Conditions
PubMed

PubMed

TitleDatePubMed
Erythropoietic effect of cobalt in patients with or without anemia.
1949 May 12
Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS.
1975 May 2
Improved methods for cobalt filling and silver intensification of insect motor neurons.
1982 Jul
Acute oral toxicity of inorganic cobalt compounds in rats.
1982 Jun
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice.
1990 Aug
Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.
1990 Dec 1
Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH(2)). X-Ray Crystal Structures of [Co(bdoa)(H(2)O)(3)] 3.5H(2)O and {[CO(phen)(3)](bdoa)}(2)24H(2)O (phen = 1,10-Phenanthroline).
1999
Determination of trace metal ions in common salt by stripping voltammetry.
1999 Nov-Dec
Cobalt and antimony: genotoxicity and carcinogenicity.
2003 Dec 10
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
2005 Aug
Synthesis and antifungal potential of Co(II) complexes of 1-(2'-hydroxyphenyl) ethylideneanilines.
2006 Feb
Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.
2009 Apr
In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference.
2013 Sep
In vitro evaluation of anticancer and antibacterial activities of cobalt oxide nanoparticles.
2015 Dec
Purification and characterization of glucose 6-phosphate dehydrogenase enzyme from rainbow trout (Oncorhynchus mykiss) liver and investigation of the effects of some metal ions on enzyme activity.
2015 May
Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice.
2016 Aug 15
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:51:36 GMT 2025
Edited
by admin
on Mon Mar 31 20:51:36 GMT 2025
Record UNII
V9X9644V7Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZAFFRE
Preferred Name English
COBALTOUS OXIDE
HSDB   MI  
Common Name English
COBALT BLACK
Common Name English
COBALTOUS OXIDE [HSDB]
Common Name English
C.I. 77322
Common Name English
COBALTOUS OXIDE [MI]
Common Name English
CI 77322
Common Name English
COBALT(2+) OXIDE
Common Name English
COBALT MONOXIDE
Common Name English
C.I. PIGMENT BLACK 13
Common Name English
COBALT OXIDE (COO)
Common Name English
COBALT(II) OXIDE
Common Name English
Code System Code Type Description
PUBCHEM
9942118
Created by admin on Mon Mar 31 20:51:36 GMT 2025 , Edited by admin on Mon Mar 31 20:51:36 GMT 2025
PRIMARY
MERCK INDEX
m3700
Created by admin on Mon Mar 31 20:51:36 GMT 2025 , Edited by admin on Mon Mar 31 20:51:36 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID6051649
Created by admin on Mon Mar 31 20:51:36 GMT 2025 , Edited by admin on Mon Mar 31 20:51:36 GMT 2025
PRIMARY
ECHA (EC/EINECS)
215-154-6
Created by admin on Mon Mar 31 20:51:36 GMT 2025 , Edited by admin on Mon Mar 31 20:51:36 GMT 2025
PRIMARY
WIKIPEDIA
COBALT(II) OXIDE
Created by admin on Mon Mar 31 20:51:36 GMT 2025 , Edited by admin on Mon Mar 31 20:51:36 GMT 2025
PRIMARY
FDA UNII
V9X9644V7Q
Created by admin on Mon Mar 31 20:51:36 GMT 2025 , Edited by admin on Mon Mar 31 20:51:36 GMT 2025
PRIMARY
CAS
1307-96-6
Created by admin on Mon Mar 31 20:51:36 GMT 2025 , Edited by admin on Mon Mar 31 20:51:36 GMT 2025
PRIMARY
HSDB
239
Created by admin on Mon Mar 31 20:51:36 GMT 2025 , Edited by admin on Mon Mar 31 20:51:36 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE