Details
Stereochemistry | ACHIRAL |
Molecular Formula | Co.O |
Molecular Weight | 74.9326 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[O--].[Co++]
InChI
InChIKey=IUYLTEAJCNAMJK-UHFFFAOYSA-N
InChI=1S/Co.O/q+2;-2
Molecular Formula | HO |
Molecular Weight | 17.0073 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Co |
Molecular Weight | 58.933195 |
Charge | 2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pghttps://fscimage.fishersci.com/msds/05330.htmhttp://datasheets.scbt.com/sc-227251.pdfISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttps://pubchem.ncbi.nlm.nih.gov/compound/104729Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14643417 | https://www.ncbi.nlm.nih.gov/pubmed/16244201
Sources: ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pghttps://fscimage.fishersci.com/msds/05330.htmhttp://datasheets.scbt.com/sc-227251.pdfISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttps://pubchem.ncbi.nlm.nih.gov/compound/104729
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14643417 | https://www.ncbi.nlm.nih.gov/pubmed/16244201
Cobalt is a transition metal, naturally ocurring in the minerals cobaltite, smaltite, and erythrite, and is often associated with nickel, silver, lead, copper, and iron ores, from which it is most frequently obtained as a by-product. Depending on the considered species, cobalt has multiple industrial applications including the production of alloys and hard metal, diamond polishing, drying agents, pigments and catalysts. Cobalt is an essential component of Vitamin B12 (hydroxycolalamin). Cobalt functions as a co-factor in enzyme catalysed reactions and is involved in the production of erythropoietin, a hormone that stimulates the formation of erythrocytes. Cobalt salts were used to treat anemia and stimulate erythropoiesis, but was withdrawn from market since Co(II) cations are genotoxic in vitro and in vivo, and carcinogenic in rodents. Hovewer, Co salts are reported to be used by athletes as a doping
Originator
Sources: http://www.rsc.org/periodic-table/element/27/cobalt
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q9NWT6 Gene ID: 55662.0 Gene Symbol: HIF1AN Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15941769 |
1.0 µM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Erythropoietic effect of cobalt in patients with or without anemia. | 1949 May 12 |
|
Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS. | 1975 May 2 |
|
Improved methods for cobalt filling and silver intensification of insect motor neurons. | 1982 Jul |
|
Acute oral toxicity of inorganic cobalt compounds in rats. | 1982 Jun |
|
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice. | 1990 Aug |
|
Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes. | 1990 Dec 1 |
|
Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH(2)). X-Ray Crystal Structures of [Co(bdoa)(H(2)O)(3)] 3.5H(2)O and {[CO(phen)(3)](bdoa)}(2)24H(2)O (phen = 1,10-Phenanthroline). | 1999 |
|
Determination of trace metal ions in common salt by stripping voltammetry. | 1999 Nov-Dec |
|
Cobalt and antimony: genotoxicity and carcinogenicity. | 2003 Dec 10 |
|
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway. | 2005 Aug |
|
Synthesis and antifungal potential of Co(II) complexes of 1-(2'-hydroxyphenyl) ethylideneanilines. | 2006 Feb |
|
Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals. | 2009 Apr |
|
In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference. | 2013 Sep |
|
In vitro evaluation of anticancer and antibacterial activities of cobalt oxide nanoparticles. | 2015 Dec |
|
Purification and characterization of glucose 6-phosphate dehydrogenase enzyme from rainbow trout (Oncorhynchus mykiss) liver and investigation of the effects of some metal ions on enzyme activity. | 2015 May |
|
Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice. | 2016 Aug 15 |
Substance Class |
Chemical
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V9X9644V7Q
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COBALT(II) OXIDE
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PARENT -> SALT/SOLVATE |