ENDIXAPRINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H15Cl2N3O
Molecular Weight	324.205
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1CCN(CC1)C2=NN=C(C=C2)C3=C(Cl)C=C(Cl)C=C3

InChI

InChIKey=COWWILCLLRVLSC-UHFFFAOYSA-N

InChI=1S/C15H15Cl2N3O/c16-10-1-2-12(13(17)9-10)14-3-4-15(19-18-14)20-7-5-11(21)6-8-20/h1-4,9,11,21H,5-8H2

HIDE SMILES / InChI

Molecular Formula	C15H15Cl2N3O
Molecular Weight	324.205
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1299328 | https://www.ncbi.nlm.nih.gov/pubmed/2875399 | https://www.ncbi.nlm.nih.gov/pubmed/3095540 | https://adisinsight.springer.com/drugs/800000722

Endixaprine (SR 41378 or 3-(4-hydroxy-1-piperidinyl)-6-(2,4-dichlorophenyl)-pyridazine) is a aminopyridazine derivative. Endixaprine is a nonbenzodiazepine compound with a pharmacological profile similar to barbiturates and benzodiazepines. It possesses anticonflict, anticonvulsant, antianxiety and hypnotic activities in rodents.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

rats: 1.25-20 mg/kg (i.p.); 10-100 mg/kg (p.o.)

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:25:00 GMT 2023` Edited by `admin` on `Sat Dec 16 17:25:00 GMT 2023`
Record UNII	V8674RM5KM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ENDIXAPRINE

Official Name

English

1-(6-(2,4-DICHLOROPHENYL)-3-PYRIDAZINYL)-4-PIPERIDINOL

Systematic Name

English

endixaprine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C264