ENDIXAPRINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H15Cl2N3O
Molecular Weight	324.205
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1CCN(CC1)C2=NN=C(C=C2)C3=C(Cl)C=C(Cl)C=C3

InChI

InChIKey=COWWILCLLRVLSC-UHFFFAOYSA-N

InChI=1S/C15H15Cl2N3O/c16-10-1-2-12(13(17)9-10)14-3-4-15(19-18-14)20-7-5-11(21)6-8-20/h1-4,9,11,21H,5-8H2

HIDE SMILES / InChI

Molecular Formula	C15H15Cl2N3O
Molecular Weight	324.205
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1299328 | https://www.ncbi.nlm.nih.gov/pubmed/2875399 | https://www.ncbi.nlm.nih.gov/pubmed/3095540 | https://adisinsight.springer.com/drugs/800000722

Endixaprine (SR 41378 or 3-(4-hydroxy-1-piperidinyl)-6-(2,4-dichlorophenyl)-pyridazine) is a aminopyridazine derivative. Endixaprine is a nonbenzodiazepine compound with a pharmacological profile similar to barbiturates and benzodiazepines. It possesses anticonflict, anticonvulsant, antianxiety and hypnotic activities in rodents.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects.	1982	6292984
Quantitative electroencephalographic profile of 3-(4-hydroxy-1-piperidinyl)-6-(2,4-dichlorophenyl)-pyridazine (SR 41378) in the rat.	1986 Jun	2875399
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.	1986 Mar	3950916

Sample Use Guides

In Vivo Use Guide

rats: 1.25-20 mg/kg (i.p.); 10-100 mg/kg (p.o.)

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:25:00 GMT 2023` Edited by `admin` on `Sat Dec 16 17:25:00 GMT 2023`
Record UNII	V8674RM5KM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ENDIXAPRINE

Official Name

English

1-(6-(2,4-DICHLOROPHENYL)-3-PYRIDAZINYL)-4-PIPERIDINOL

Systematic Name

English

endixaprine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C264