Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C42H36N10O10S |
| Molecular Weight | 872.861 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=O)CC[C@H](N(CCNC(=S)NC1=CC2=C(C=C1)C3(OC2=O)C4=C(OC5=C3C=CC(O)=C5)C=C(O)C=C4)C(=O)C6=CC=C(NCC7=CN=C8N=C(N)NC(=O)C8=N7)C=C6)C(O)=O
InChI
InChIKey=ZMTAPBHUSYTHBY-PMERELPUSA-N
InChI=1S/C42H36N10O10S/c43-33(55)12-11-30(38(58)59)52(37(57)20-1-3-21(4-2-20)46-18-23-19-47-35-34(48-23)36(56)51-40(44)50-35)14-13-45-41(63)49-22-5-8-27-26(15-22)39(60)62-42(27)28-9-6-24(53)16-31(28)61-32-17-25(54)7-10-29(32)42/h1-10,15-17,19,30,46,53-54H,11-14,18H2,(H2,43,55)(H,58,59)(H2,45,49,63)(H3,44,47,50,51,56)/t30-/m0/s1
| Molecular Formula | C42H36N10O10S |
| Molecular Weight | 872.861 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
EC17 (also known as Folate-FITC) is conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity. EC17 binds to folate receptors, which are overexpressed on the surfaces of many cancer cells including kidney and ovarian cancer cells. Once bound to the cancer cell through the folate moiety of the conjugate, circulating anti-fluorescein antibodies recognize and bind to the FITC moiety, resulting in antibody-dependent cellular cytotoxicity. EC17 is participating in phase II clinical trials for the treatment of patients with endometrial cancer, endometriosis, lung cancer, renal cell carcinoma. In January 2018, On Target Laboratories initiated a phase III trial to evaluate the safety and efficacy of EC17 injection for patients with ovarian cancer.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A Phase I/Ib study of folate immune (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) with interferon-α and interleukin-2 in patients with renal cell carcinoma. | 2014 May |
|
| Intraoperative Molecular Diagnostic Imaging Can Identify Renal Cell Carcinoma. | 2016 Mar |
|
| Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17. | 2016 May 31 |
|
| Standardization and Optimization of Intraoperative Molecular Imaging for Identifying Primary Pulmonary Adenocarcinomas. | 2018 Feb |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 17 15:02:19 UTC 2022
by
admin
on
Sat Dec 17 15:02:19 UTC 2022
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| Record UNII |
V7YQ6134AE
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C1455
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DTXSID40207031
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583037-91-6
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V7YQ6134AE
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DB12559
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C62479
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