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Details

Stereochemistry ABSOLUTE
Molecular Formula C42H36N10O10S
Molecular Weight 872.861
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EC-17

SMILES

NC(=O)CC[C@H](N(CCNC(=S)NC1=CC2=C(C=C1)C3(OC2=O)C4=C(OC5=C3C=CC(O)=C5)C=C(O)C=C4)C(=O)C6=CC=C(NCC7=CN=C8N=C(N)NC(=O)C8=N7)C=C6)C(O)=O

InChI

InChIKey=ZMTAPBHUSYTHBY-PMERELPUSA-N
InChI=1S/C42H36N10O10S/c43-33(55)12-11-30(38(58)59)52(37(57)20-1-3-21(4-2-20)46-18-23-19-47-35-34(48-23)36(56)51-40(44)50-35)14-13-45-41(63)49-22-5-8-27-26(15-22)39(60)62-42(27)28-9-6-24(53)16-31(28)61-32-17-25(54)7-10-29(32)42/h1-10,15-17,19,30,46,53-54H,11-14,18H2,(H2,43,55)(H,58,59)(H2,45,49,63)(H3,44,47,50,51,56)/t30-/m0/s1

HIDE SMILES / InChI

Molecular Formula C42H36N10O10S
Molecular Weight 872.861
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

EC17 (also known as Folate-FITC) is conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity. EC17 binds to folate receptors, which are overexpressed on the surfaces of many cancer cells including kidney and ovarian cancer cells. Once bound to the cancer cell through the folate moiety of the conjugate, circulating anti-fluorescein antibodies recognize and bind to the FITC moiety, resulting in antibody-dependent cellular cytotoxicity. EC17 is participating in phase II clinical trials for the treatment of patients with endometrial cancer, endometriosis, lung cancer, renal cell carcinoma. In January 2018, On Target Laboratories initiated a phase III trial to evaluate the safety and efficacy of EC17 injection for patients with ovarian cancer.

Approval Year

PubMed

PubMed

TitleDatePubMed
A Phase I/Ib study of folate immune (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) with interferon-α and interleukin-2 in patients with renal cell carcinoma.
2014 May
Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17.
2016 May 31

Sample Use Guides

Patients received 0.1 mg/kg EC17 intravenously over 10 minutes, 2-3 hours before surgery.
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Sat Dec 16 03:01:47 UTC 2023
Edited
by admin
on Sat Dec 16 03:01:47 UTC 2023
Record UNII
V7YQ6134AE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EC-17
Common Name English
EC17 (FOLATE-FITC)
Common Name English
L-GLUTAMINE, N2-(4-(((2-AMINO-3,4-DIHYDRO-4-OXO-6-PTERIDINYL)METHYL)AMINO)BENZOYL)-N-(2-((((3',6'-DIHYDROXY-3-OXOSPIRO(ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN)-5-YL)AMINO)THIOXOMETHYL)AMINO)ETHYL)-
Common Name English
EC 17 [WHO-DD]
Common Name English
FOLATE-FITC
Common Name English
FOLATE-FLUORESCEIN CONJUGATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1455
Created by admin on Sat Dec 16 03:01:47 UTC 2023 , Edited by admin on Sat Dec 16 03:01:47 UTC 2023
Code System Code Type Description
PUBCHEM
135564966
Created by admin on Sat Dec 16 03:01:47 UTC 2023 , Edited by admin on Sat Dec 16 03:01:47 UTC 2023
PRIMARY
EPA CompTox
DTXSID40207031
Created by admin on Sat Dec 16 03:01:47 UTC 2023 , Edited by admin on Sat Dec 16 03:01:47 UTC 2023
PRIMARY
CAS
583037-91-6
Created by admin on Sat Dec 16 03:01:47 UTC 2023 , Edited by admin on Sat Dec 16 03:01:47 UTC 2023
PRIMARY
FDA UNII
V7YQ6134AE
Created by admin on Sat Dec 16 03:01:47 UTC 2023 , Edited by admin on Sat Dec 16 03:01:47 UTC 2023
PRIMARY
SMS_ID
100000175109
Created by admin on Sat Dec 16 03:01:47 UTC 2023 , Edited by admin on Sat Dec 16 03:01:47 UTC 2023
PRIMARY
DRUG BANK
DB12559
Created by admin on Sat Dec 16 03:01:47 UTC 2023 , Edited by admin on Sat Dec 16 03:01:47 UTC 2023
PRIMARY
NCI_THESAURUS
C62479
Created by admin on Sat Dec 16 03:01:47 UTC 2023 , Edited by admin on Sat Dec 16 03:01:47 UTC 2023
PRIMARY
Related Record Type Details
TARGET->LIGAND
Related Record Type Details
ACTIVE MOIETY