Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | 2C27H26F3N3O2.3C4H4O4 |
| Molecular Weight | 1311.2354 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 3 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.FC(F)(F)OC1=CC(CN2CCC(CC2)N3[C@@H](C4=CC=CC=C4)C5=C(NC3=O)C=CC=C5)=CC=C1.FC(F)(F)OC6=CC(CN7CCC(CC7)N8[C@@H](C9=CC=CC=C9)C%10=C(NC8=O)C=CC=C%10)=CC=C6
InChI
InChIKey=WOIRJIDJKVWHJX-CVZQVWBPSA-N
InChI=1S/2C27H26F3N3O2.3C4H4O4/c2*28-27(29,30)35-22-10-6-7-19(17-22)18-32-15-13-21(14-16-32)33-25(20-8-2-1-3-9-20)23-11-4-5-12-24(23)31-26(33)34;3*5-3(6)1-2-4(7)8/h2*1-12,17,21,25H,13-16,18H2,(H,31,34);3*1-2H,(H,5,6)(H,7,8)/b;;3*2-1+/t2*25-;;;/m00.../s1
| Molecular Formula | C4H4O4 |
| Molecular Weight | 116.0722 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
| Molecular Formula | C27H26F3N3O2 |
| Molecular Weight | 481.5094 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Afacifenacin is being developed by Sumitomo Dainippon Pharma (formerly Dainippon Sumitomo Pharma) and Sunovion Pharmaceuticals as an orally administered therapy for overactive bladder and nocturia. Afacifenacin is a new antimuscarinic that possesses the dual
pharmacological actions of non-selective muscarinic receptor
antagonist and inhibition of the bladder afferent pathway
through sodium-channel blockade. Afacifenacin is in Phase II clinical tirals for the treatment of Nocturia by Nippon Shinyaku.
Originator
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:47:00 UTC 2023
by
admin
on
Fri Dec 15 15:47:00 UTC 2023
|
| Record UNII |
V6IS459I5G
|
| Record Status |
Validated (UNII)
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| Record Version |
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133082921
Created by
admin on Fri Dec 15 15:47:00 UTC 2023 , Edited by admin on Fri Dec 15 15:47:00 UTC 2023
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500593-73-7
Created by
admin on Fri Dec 15 15:47:00 UTC 2023 , Edited by admin on Fri Dec 15 15:47:00 UTC 2023
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V6IS459I5G
Created by
admin on Fri Dec 15 15:47:00 UTC 2023 , Edited by admin on Fri Dec 15 15:47:00 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE |
